13

Alvelestat

13 Publications Verification

Cat. No.: HY-15651

CAS No.: 848141-11-7

Purity: 99.87%

Synonyms: AZD9668

Target:

Elastase Claudin Interleukin Related MMP

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .

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6

IAXO-102

6 Cited Publications

Cat. No.: HY-125171

CAS No.: 1115270-63-7

Purity: ≥98.0%

Target:

Toll-like Receptor (TLR)

Research Areas:

Inflammation/Immunology

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .

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4

Calcium chloride anhydrous, for cell culture

4 Cited Publications

Cat. No.: HY-Y0406E

CAS No.: 10043-52-4

Synonyms: Calcium dichloride anhydrous, for cell culture

Calcium chloride anhydrous, for cell culture is an inorganic salt for the preparation of various buffers . Calcium chloride anhydrous, for cell culture can be used for animal modeling, to construct abdominal aortic aneurysm models .

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2

Tamsulosin

2 Cited Publications

Cat. No.: HY-B0661

CAS No.: 106133-20-4

Synonyms: (R)-(-)-YM12617 free base; LY253351 free base

Target:

Adrenergic Receptor Apoptosis

Research Areas:

Neurological Disease Endocrinology Cancer

Tamsulosin ((R)-(-)-YM12617 free base) is an orally active antagonist of α₁-adrenergic receptor. Tamsulosin induces Apoptosis. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models .

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2

Tamsulosin hydrochloride

2 Cited Publications

Cat. No.: HY-B0661A

CAS No.: 106463-17-6

Synonyms: (R)-(-)-YM12617; LY253351

Category:

Neurological Disease Disease Research Fields Endocrinology

Target:

Adrenergic Receptor Apoptosis

Tamsulosin hydrochloride ((R)-(-)-YM12617 free base) is an orally active antagonist of α₁-adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models .

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2

PF-04217903

2 Cited Publications

Cat. No.: HY-12017

CAS No.: 956905-27-4

Purity: 99.85%

Target:

c-Met/HGFR Apoptosis Akt Phospholipase Annexin A

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology Cancer

PF-04217903 is an orally active, highly selective ATP-competitive c-Met kinase inhibitor with a K_i value of 4.8 nM and a K_d value of 4.5 nM. PF-04217903 blocks c-Met and HGF signaling pathways, inhibits MET phosphorylation, and blocks downstream MAPK, PI3K/AKT and PLCγ1 pathways. PF-04217903 suppresses tumor proliferation, survival, migration, invasion, angiogenesis and metastasis, induces apoptosis, and enhances efferocytosis, Annexin A1 expression and resolution of inflammation. PF-04217903 retains activity against several c-Met mutants (M1131T, V1220I, H1094R). PF-04217903 increases the incidence of subarachnoid hemorrhage and reduces survival rate without altering aneurysm formation, and also prevents lymph node metastasis induced by VEGF inhibition. PF-04217903 is applicable to research related to tumors (pancreas, stomach, lung, brain, colon, breast, kidney, melanoma, etc.), intracranial aneurysms and inflammatory diseases (gouty arthritis, neutrophilic pleuritis) .

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2

PF-04217903 mesylate

2 Cited Publications

Cat. No.: HY-12017A

CAS No.: 956906-93-7

Purity: 99.82%

Target:

c-Met/HGFR Apoptosis Akt Phospholipase Annexin A

PF-04217903 mesylate is an orally active, highly selective ATP-competitive c-Met kinase inhibitor with a K_i value of 4.8 nM and a K_d value of 4.5 nM. PF-04217903 mesylate blocks c-Met and HGF signaling pathways, inhibits MET phosphorylation, and blocks downstream MAPK, PI3K/AKT and PLCγ1 pathways. PF-04217903 mesylate suppresses tumor proliferation, survival, migration, invasion, angiogenesis and metastasis, induces apoptosis, and enhances efferocytosis, Annexin A1 expression and resolution of inflammation. PF-04217903 mesylate retains activity against several c-Met mutants (M1131T, V1220I, H1094R). PF-04217903 mesylate increases the incidence of subarachnoid hemorrhage and reduces survival rate without altering aneurysm formation, and also prevents lymph node metastasis induced by VEGF inhibition. PF-04217903 mesylate is applicable to research related to tumors (pancreas, stomach, lung, brain, colon, breast, kidney, melanoma, etc.), intracranial aneurysms and inflammatory diseases (gouty arthritis, neutrophilic pleuritis) .

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1

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34)

1 Cited Publications

Cat. No.: HY-P990209

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-7Rα/CD127. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) blocks IL-7 signaling. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) can be used for the researches of cancer,infection, inflammation, immunology, cardiovascular and metabolic disease, such as abdominal aortic aneurysms, helicobacter felis-induced gastritis and diabetes .

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1

mLR12

1 Cited Publications

Cat. No.: HY-P5521

CAS No.: 3033299-76-9

Target:

Inhibitory Antibodies

Research Areas:

Cardiovascular Disease

mLR12 is a Trem1 inhibitory peptide. mLR12 decreases aortic rupture rate in BAPN-induced Thoracic aortic aneurysm and dissection (TAAD) mice model .

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Satralizumab

Cat. No.: HY-P99112

CAS No.: 1535963-91-7

Synonyms: RG-6168; SA-237

Satralizumab is a humanized monoclonal antibody that targets IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research .

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SB-273005

Cat. No.: HY-19307

CAS No.: 205678-31-5

Target:

Integrin Interleukin Related

Research Areas:

Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer

SB-273005 is an orally active non-peptide αvβ3 integrin antagonist with K_i values of 1.2 nM and 0.3 nM for αvβ3 and αvβ5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. .

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Imidapril hydrochloride

Cat. No.: HY-B1451

CAS No.: 89396-94-1

Synonyms: TA-6366

Target:

Angiotensin-converting Enzyme (ACE) MMP JNK

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology

Imidapril hydrochloride (TA-6366) is an orally active dual inhibitor of angiotensin-converting enzyme (ACE) and MMP-9. Imidapril hydrochloride inhibits lipopolysaccharide-induced phosphorylation of c-Jun, MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10, thereby exerting anti-inflammatory activity. Imidapril hydrochloride also effectively ameliorates mesangial expansion and reduces urinary albumin excretion by inhibiting angiotensin AngII production, lowering glomerular pressure and oxidative stress, thus delaying disease progression. Imidapril hydrochloride can also directly bind to the active site of MMP-9 to inhibit gelatinase activity, and suppress the enlargement of cerebral aneurysms without altering systemic blood pressure. Imidapril hydrochloride is widely applicable to related studies on autoimmune glomerulonephritis, diabetic nephropathy, cerebral aneurysms and other conditions .

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Trisdecanoin

Cat. No.: HY-N6660

CAS No.: 621-71-6

Synonyms: Tricaprin; Glyceryl tridecanoate

Category:

Lauraceae Extract Ketones, Aldehydes, Acids 500 - Internal Server Error | MedChemExpress

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