8

TRi-1

8 Publications Verification

Cat. No.: HY-125006

CAS No.: 246020-68-8

Purity: 99.91%

Target:

JNK p38 MAPK

Research Areas:

Cancer

TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC₅₀ of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy .

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5

Tioconazole

5 Cited Publications

Cat. No.: HY-B0319

CAS No.: 65899-73-2

Synonyms: UK-20349

Target:

Fungal Antibiotic Parasite Akt PI3K mTOR Autophagy

Research Areas:

Infection Cancer

Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC₅₀ values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy .

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2

Hypocrellin A

2 Cited Publications

Cat. No.: HY-N2575

CAS No.: 77029-83-5

Category:

Infection Quinones Microorganisms Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:

PKC Bacterial Parasite HIV VSV VEGFR Bcl-2 Family Apoptosis

Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC₅₀=0.27 μg/ml) .

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1

BNN6

1 Cited Publications

Cat. No.: HY-164117

CAS No.: 106476-75-9

Target:

Reactive Oxygen Species (ROS) Apoptosis

Research Areas:

Cancer

BNN6 is a thermoresponsive nitric oxide (NO) donor that often works by binding to a carrier. BNN6 decomposes under the heat stimulation generated by photothermal action, releasing high concentrations of NO, which exerts anti-tumor activity by inducing tumor cell apoptosis and inhibiting their repair. BNN6 can be used to synthesize the multifunctional biosensor BNN6-BiTiS3-iRGD, which exerts a synergistic anti-cancer effect with photothermal therapy (PTT) .

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Borocaptate sodium

Cat. No.: HY-142041

CAS No.: 144885-51-8

Purity: ≥95.0%

Synonyms: BSH

Target:

Biochemical Assay Reagents

Research Areas:

Cancer

Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity .

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PCNA-I1

Cat. No.: HY-124012

CAS No.: 444930-42-1

Purity: 99.20%

Target:

DNA/RNA Synthesis Apoptosis

Research Areas:

Cancer

PCNA-I1 is a selective small molecule inhibitor targeting proliferating cell nuclear antigen (PCNA) with anticancer activity. PCNA-I1 can stabilize the PCNA trimer structure (Kd=0.14-0.41μM), reduce its binding to chromatin, induce tumor cell cycle arrest, inhibit DNA replication and repair, and enhance the anti-tumor effect of DNA damaging agents. PCNA-I1 can be used in the study of targeted therapy for prostate cancer, lung cancer and other tumors .

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BPR1K871

Cat. No.: HY-100865

CAS No.: 2443767-35-7

Purity: 99.12%

Synonyms: DBPR114

Target:

FLT3

Research Areas:

Cancer

BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC₅₀s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy .

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Borocaptate-10B12 sodium

Cat. No.: HY-114376

CAS No.: 12448-24-7

Synonyms: BSH-¹⁰B₁₂

Borocaptate-10B12 (BSH-10B12) sodium is a boron-10 labeled Borocaptate (HY-142041). Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity .

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3-Chlorogentisyl alcohol

Cat. No.: HY-151168

CAS No.: 32744-80-2

Purity: 99.70%

Target:

β-glucuronidase Bacterial

Research Areas:

Inflammation/Immunology Cancer

3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC₅₀ value of 0.74 μM, an K_i value of 0.58 μM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies .

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PVTX-405

Cat. No.: HY-172930

CAS No.: 2991021-08-8

Target:

Molecular Glues IKZF Family Potassium Channel

Research Areas:

Inflammation/Immunology Cancer

PVTX-405 is a selective and oral active IKZF2 molecular glue degrader with a DC₅₀ of 0.7 nM and a D_max of 91%. PVTX-405 enhances degradation efficiency, significantly reduces off-target degradation, and alleviates hERG inhibition with IC₅₀ of 48 µM. PVTX-405 significantly inhibits the growth of MC38 tumors, with greater synergistic anti-cancer efficacy in combination with immune checkpoint therapies (ICTs) (anti-PD1 or anti-LAG3) in the MC38 mouse tumor xenograft model using Crbn ^391V C57BL/6 mice .

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QNX-10

Cat. No.: HY-175020

Target:

Fatty Acid Synthase (FASN) Apoptosis Bcl-2 Family

Research Areas:

Cancer

QNX-10 is a fatty acid synthase (FASN) inhibitor (IC₅₀ = 0.7 μM) with anticancer activity. QNX-10 exhibits potent FASN inhibition and cytotoxicity against colorectal and breast cancer cells. QNX-10 induces apoptosis and cell cycle arrest in S phase by upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-xL. QNX-10 can be used to investigate anticancer therapies targeting FASN enzymes .

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