6

Lithium chloride hydrate

6 Publications Verification

Cat. No.: HY-W094474

CAS No.: 85144-11-2

Synonyms: hydrate/monohydrateortrihydrate

Target:

GSK-3 Apoptosis

Research Areas:

Infection Neurological Disease

Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease .

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6

Phenelzine sulfate

6 Publications Verification

Cat. No.: HY-B1018A

CAS No.: 156-51-4

Target:

Monoamine Oxidase GABA Receptor Histone Demethylase

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

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4

Nefazodone

4 Cited Publications

Cat. No.: HY-119209

CAS No.: 83366-66-9

Purity: 98.01%

Target:

5-HT Receptor Cytochrome P450

Research Areas:

Neurological Disease Inflammation/Immunology

Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT_2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction .

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2

Hypidone hydrochloride

2 Cited Publications

Cat. No.: HY-100769

CAS No.: 1339058-04-6

Purity: 99.73%

Synonyms: YL0919

Target:

5-HT Receptor

Research Areas:

Neurological Disease

Hypidone hydrochloride (YL0919) is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptake blocker and an effective 5-HT_1A receptor agonist (K_i=0.19 nM). Hypidone hydrochloride inhibits the uptake of [ ³H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells with IC₅₀s of 1.78 nM and 1.93 nM, respectively. Hypidone hydrochloride shows remarkable antidepressant effects in animal models and has the poential for the investigation of depressive disorder .

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1

Mirtazapine

1 Cited Publications

Cat. No.: HY-B0352

CAS No.: 85650-52-8

Synonyms: Org3770; 6-Azamianserin

Target:

5-HT Receptor Histamine Receptor Adrenergic Receptor

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT₂, 5-HT₃, histamine H1 receptor and α2-adrenoceptor antagonist with pK_i values of 8.05, 8.1, 9.3 and 6.95, respectively .

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1

Hydroxybupropion

1 Cited Publications

Cat. No.: HY-100637

CAS No.: 92264-81-8

Purity: 99.91%

Target:

Drug Metabolite Adrenergic Receptor nAChR

Research Areas:

Neurological Disease

Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6. Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC₅₀ value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonist .

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1

EGLU

1 Cited Publications

Cat. No.: HY-101332

CAS No.: 170984-72-2

Purity: 99.79%

Synonyms: (2S)-α-Ethylglutamic acid; (2S)-α-EGLU

Target:

mGluR

Research Areas:

Neurological Disease

EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a K_d value of 66 μM. EGLU is an antidepressant agent .

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Gepirone

Cat. No.: HY-122422

CAS No.: 83928-76-1

Purity: 99.88%

Target:

5-HT Receptor

Research Areas:

Others

Gepirone is a selective and affinitive 5-HT_1A agonist. Gepirone binds selectively to 5-HT_1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research .

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ZZL-7

Cat. No.: HY-148417

CAS No.: 99141-91-0

Purity: 98.92%

Target:

Serotonin Transporter

Research Areas:

Neurological Disease

ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD) .

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Melitracen hydrochloride

Cat. No.: HY-108256

CAS No.: 10563-70-9

Purity: 99.90%

Target:

5-HT Receptor

Research Areas:

Neurological Disease

Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space .

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