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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
antimitotic agent
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "antimitotic agent" in MCE Product Catalog:
101
101 Publications Verification
Synonyms: MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin
Research Areas:
VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
24
24 Cited Publications
Synonyms: KW-2307; Nor-5'-anhydrovinblastine ditartrate
Category:
Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Disease Research Fields Cancer Alkaloid Dimers Apocynaceae Extract
Target:
8
8 Cited Publications
Synonyms: Vanillylacetone; Gingerone
Category:
Plant Monophenols Zingiberaceae Extract Ketones, Aldehydes, Acids Metabolic Disease Phenols Zingiber officinale Roscoe Extract Disease Research Fields Inflammation/Immunology
Target:
3
3 Cited Publications
Cat. No.: HY-100566
Purity: 99.24%
Target:
Research Areas:
SuO-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the peptide SuO-Val-Cit-PAB .
2
2 Cited Publications
Synonyms: NHS-VC-PAB-MMAE
Target:
Research Areas:
SC-VC-PAB-MMAE (NHS-VC-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB .
2
2 Cited Publications
Cat. No.: HY-12053AS
Purity: ≥98.0%
Synonyms: KW-2307-d3 ditartrate; Nor-5'-anhydrovinblastine-d3 ditartrate
1
1 Cited Publications
Cat. No.: HY-W190943
CAS No.: 1869126-64-6
Target:
Research Areas:
Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH . Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-P990673
Synonyms: DSTP-3086S Antibody; RG-7450 Antibody
Research Areas:
Cat. No.: HY-15575S
Purity: 97.56%
Synonyms: MC-Val-Cit-PAB-MMAE-d8; mc-vc-PAB-MMAE-d8
Cat. No.: HY-12053
CAS No.: 71486-22-1
Synonyms: KW-2307 base
Target:
Research Areas:
Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
Target:
Research Areas:
Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis .
Cat. No.: HY-P99705
CAS No.: 1401812-88-1
Synonyms: RG-7599; DNIB-0600A; NaPi2b-ADC
Target:
Research Areas:
Lifastuzumab vedotin (RG-7599; DNIB0600A) is an antibody-drug conjugate (ADC) that comprises a humanized IgG1 anti-NaPi2b monoclonal antibody (MNIB2126A) and a potent antimitotic agent, monomethyl auristatin E (MMAE), which inhibits cell division by blocking the polymerization of tubulin. Lifastuzumab vedotin has the potential for non-small cell lung cancer (NSCLC) and platinum-resistant ovarian cancer (PROC) research .
Synonyms: NSC656158
Target:
Research Areas:
CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity .
Cat. No.: HY-P1126
CAS No.: 123884-00-4
Synonyms: DLS 15
Target:
Research Areas:
Cat. No.: HY-N10958
CAS No.: 159736-35-3
Category:
Target:
0 Images
Sgc8c-M
Cat. No.: HY-177571
Synonyms: Sgc8c-VcMMAE
Cat. No.: HY-101741
CAS No.: 256934-83-5
Synonyms: A-289099
Target:
Research Areas:
A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED50 values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer .
Cat. No.: HY-177274
CAS No.: 182878-97-3
Target:
Research Areas:
Antimitotic agent-2 (Compound 1) is an antimitotic agent. Antimitotic agent-2 inhibits the proliferation of human epidermal cells. Antimitotic agent-2 can be used in hyperproliferative skin disorders .
Cat. No.: HY-125124
CAS No.: 865852-47-7
Target:
- 1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
