5 Results for "

antiparallel β-sheet

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "antiparallel β-sheet" in MCE Product Catalog:

Vm24-toxin TFA
Vm24-toxin TFA
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Cat. No.: HY-P5917A
Synonyms: Vaejovis mexicanus peptide 24 TFA
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology Cancer

Vm24-toxin (Vaejovis mexicanus peptide 24) TFA, a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin TFA shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin TFA folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin TFA attenuates the CD4 + effector memory T cell response to T cell receptor (TCR) stimulation .
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Vm24-toxin
Vm24-toxin
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Cat. No.: HY-P5917
CAS No.: 1373890-79-9
Synonyms: Vaejovis mexicanus peptide 24
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology Cancer

Vm24-toxin (Vaejovis mexicanus peptide 24), a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin attenuates the CD4 + effector memory T cell response to T cell receptor (TCR) stimulation .
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Amyloid-Forming peptide GNNQQNY
Amyloid-Forming peptide GNNQQNY
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Cat. No.: HY-P5340
CAS No.: 339091-39-3
Target:  

Inhibitory Antibodies

Research Areas:  

Others

Amyloid-Forming peptide GNNQQNY is a biological active peptide. (This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.)
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SPG-178
SPG-178
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Cat. No.: HY-P12358
CAS No.: 1245010-44-9
Target:  

Biochemical Assay Reagents

Research Areas:  

Metabolic Disease Inflammation/Immunology

SPG-178 is a synthetic neutral Self-assembling peptide. In neutral aqueous solution, SPG-178 spontaneously assembles into an antiparallel β-sheet nanoscale three-dimensional hydrogel (SPG-178-Gel) through electrostatic and hydrophobic interactions, and biologically mimics the natural extracellular matrix (ECM) to provide a microenvironment that promotes cell proliferation and angiogenesis .
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TDI6245
TDI6245
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Cat. No.: HY-187442
Target:  

Aurora Kinase Proteasome

Research Areas:  

Infection Cancer

TDI6245 is a Aurora kinase A (AURKA) inhibitor with an IC50 value of 21.64 nM against AURKA. TDI6245 also inhibits the β5 subunit of the 20S proteasome from Plasmodium falciparum (Pf 20S), with IC50 values of 0.11 μM, 31.1 μM and 6.8 μM against Pf 20S β5, human constitutive proteasome β5c and human immunoproteasome β5i subunits, respectively. TDI6245 binds to the AURKA pocket and the substrate cleft of Pf 20S β5 via antiparallel β-sheets and hydrogen bonds. TDI6245 inhibits the growth of Plasmodium falciparum. TDI6245 can be used in research related to triple-negative breast cancer and malaria .
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