52

Zenidolol

52 Publications Verification

Cat. No.: HY-100543

CAS No.: 72795-26-7

Purity: 99.60%

Synonyms: ICI-118551

Target:

Adrenergic Receptor Apoptosis Caspase Bcl-2 Family HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Zenidolol (ICI-118551) is a selective β2-adrenergic receptor antagonist with K_i values of Zenidolol for β2, β1 and β3 adrenergic receptors of 0.7, 49.5 and 611 nM, respectively. Zenidolol exerts antitumor effects via inducing apoptosis, inhibiting tumor sphere formation, and downregulating the HIF pathway by blocking β2-AR on tumor cells. Zenidolol exhibits a unique pulmonary vessel-specific vasodilatory effect in mouse models. Zenidolol can be used as an intraocular pressure-lowering agent in ophthalmic disease research .

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38

C188-9

38 Cited Publications

Cat. No.: HY-112288

CAS No.: 432001-19-9

Purity: 99.90%

Synonyms: TTI-101

Target:

STAT Apoptosis DNA Methyltransferase

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

C188-9 (TTI-101) is a STAT3 inhibitor with a K_d value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .

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35

K-975

35 Cited Publications

Cat. No.: HY-138565

CAS No.: 2563855-03-6

Purity: 99.89%

Target:

YAP

Research Areas:

Cancer

K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma .

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31

Capmatinib

31 Cited Publications

Cat. No.: HY-13404

CAS No.: 1029712-80-8

Purity: 99.75%

Synonyms: INC280; INCB28060

Target:

c-Met/HGFR Apoptosis

Research Areas:

Cancer

Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase .

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31

Capmatinib dihydrochloride

31 Cited Publications

Cat. No.: HY-13404A

CAS No.: 1197376-85-4

Synonyms: INC280 dihydrochloride; INCB28060 dihydrochloride

Target:

c-Met/HGFR Apoptosis

Research Areas:

Cancer

Capmatinib (INC280; INCB28060) dihydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib dihydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase .

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31

Capmatinib hydrochloride

31 Cited Publications

Cat. No.: HY-13404B

CAS No.: 1029714-89-3

Purity: 99.60%

Synonyms: INC280 hydrochloride; INCB-28060 hydrochloride

Target:

c-Met/HGFR Apoptosis

Research Areas:

Cancer

Capmatinib (INC280; INCB28060) hydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib hydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib hydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib hydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase .

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31

Capmatinib dihydrochloride hydrate

31 Cited Publications

Cat. No.: HY-13404C

CAS No.: 1865733-40-9

Purity: 99.78%

Synonyms: INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate

Target:

c-Met/HGFR Apoptosis

Research Areas:

Cancer

Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase .

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27

Erythromycin

27 Cited Publications

Cat. No.: HY-B0220

CAS No.: 114-07-8

Category:

Disease Research Antibacterial Infection Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:

Bacterial Antibiotic DNA/RNA Synthesis

Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid ^[1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research ^[3][4].

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27

Erythromycin lactobionate

27 Cited Publications

Cat. No.: HY-B0220A

CAS No.: 3847-29-8

Target:

Antibiotic Bacterial DNA/RNA Synthesis

Research Areas:

Infection Cancer

Erythromycin lactobionate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid ^[1][2]. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research ^[3][4].

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27

Erythromycin thiocyanate

27 Cited Publications

Cat. No.: HY-B0220D

CAS No.: 7704-67-8

Category:

Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Antibacterial Anticancer Disease Research Fields

Target:

Bacterial Antibiotic DNA/RNA Synthesis

Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid ^[1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research ^[3][4].

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