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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
apolipoprotein B
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "apolipoprotein B" in MCE Product Catalog:
4
Target:
Research Areas:
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .
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Target:
Research Areas:
Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH) .
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1 Cited Publications
Cat. No.: HY-P7533
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: APOH; Anticardiolipin Cofactor; Prev. B2G1; Beta(2)GPI; Beta-2-Glycoprotein I; B2GPI; Beta-2-Glycoprotein 1; Apo-H; BG; Epididymis Secretory Sperm Binding Protein; apolipoprotein H (Beta-2-Glycoprotein I); B2GP1; Activated Protein C-Binding Protein; Apoli
Species:
Human
Source:
HEK293
Cat. No.: HY-153491
CAS No.: 2097587-83-0
Synonyms: ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx
Target:
Research Areas:
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) is a GalNAc-modified antisense oligonucleotide. Olezarsen binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .
Target:
Carboxylesterase (CES) Free Fatty Acid Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Ferroptosis Apoptosis
Research Areas:
GR148672X is an inhibitor of carboxylesterase 1 (CES1) and hepatic microsomal triglyceride hydrolase (TGH). GR148672X blocks the catalytic activity of CES1, impairs the functions of triglyceride and cholesteryl ester lipase, reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis. GR148672X can be used in studies related to colorectal cancer and atherosclerosis .
Synonyms: ISIS 678354 sodium; IONIS-APOCIII-LRx sodium; AKCEA-APOCIII-LRx sodium
Target:
Research Areas:
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .
Cat. No.: HY-P99822
CAS No.: 2361290-85-7
Synonyms: SHR-1209
Target:
Research Areas:
Cat. No.: HY-177291
CAS No.: 256397-11-2
Research Areas:
LAB687 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.9 nM for apolipoprotein B (apoB) secretion in HepG2 cells. LAB687 also acts as a Smoothened (Smo) antagonist, with IC50 values of 2.48 μM and 3.42 μM against mouse and human Smo receptors, respectively. LAB687 reduces triglyceride and low-density lipoprotein cholesterol (LDL-C) levels, and inhibits the Hedgehog signaling pathway. LAB687 can be used in studies related to Hedgehog-dependent cancers .
Cat. No.: HY-P991574
CAS No.: 2643310-75-0
Synonyms: REG-101
Target:
Research Areas:
Cat. No.: HY-173323
CAS No.: 3070232-49-1
Target:
Research Areas:
Lp(a)-IN-7 (example 1) is a lipoprotein (a) (Lp(a)) formation inhibitor with an IC50 of 2.51 nM in conditioned media containing apolipoprotein B (apoB) and apolipoprotein(a). Lp(a)-IN-7 can be used for the study of cardiovascular disease .
Cat. No.: HY-117555
CAS No.: 1415477-76-7
Research Areas:
4010B-30 is a upregulator of apolipoprotein A-I (ApoA-I). 4010B-30 regulates ApoA-I gene expression through activation of PPARγ. 4010B-30 promotes cholesterol efflux and ABCA1 expression. 4010B-30 protects against atherosclerotic lesion development in ApoE -/- mice .
Cat. No.: HY-179364
CAS No.: 1224565-08-5
Target:
Research Areas:
PLTP-IN-1 (cpd B) is a selective phospholipid transfer protein (PLTP) inhibitor with an IC50 of 1.6 μM. PLTP-IN-1 can block the phospholipid transfer mediated by PLTP and reduce the secretion of apolipoprotein B. PLTP-IN-1 has no effect on the level of triglycerides. PLTP-IN-1 can be used for the research of metabolic disease, such as hyperlipidemia .
Cat. No.: HY-P706291
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ¹⁵N-ApoB ; ¹⁵N-ApoB-100 ; ¹⁵N-apolipoprotein B; APOB; Lipoprotein B; apolipoprotein B; APOB Protein; apolipoprotein B-100; Apo B-100; ApoB-100; ApoB-48; apolipoprotein B (Including Ag(X) Antigen); LDLCQ4; Alternative Protein APOB; FCHL2; apolipoprotein B48; FLDB
Species:
Human
Source:
E. coli
Cat. No.: HY-P7524
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: APOB; Lipoprotein B; apolipoprotein B; APOB Protein; apolipoprotein B-100; Apo B-100; ApoB-100; ApoB-48; apolipoprotein B (Including Ag(X) Antigen); LDLCQ4; Alternative Protein APOB; FCHL2; apolipoprotein B48; FLDB
Species:
Human
Source:
E. coli
Cat. No.: HY-P88961A
Synonyms: APOBR; APOB48R; apolipoprotein B receptor; apolipoprotein B-100 receptor; apolipoprotein B-48 receptor
Cat. No.: HY-P72084
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: APOE; apolipoprotein E3; Prev. AD2; APO-E; Alzheimer Disease 2 (APOE*E4-Associated, Late Onset); ApoE4; apolipoprotein E Isoform 4; Apo-E; apolipoprotein E Isoform 5; LPG; apolipoprotein E Isoform 2; apolipoprotein E; LDLCQ5
Species:
Rabbit
Source:
E. coli
Cat. No.: HY-P75504
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: APOL1; apolipoprotein L 1; Prev. APOL; APOL1 Protein; apolipoprotein L1-B3; APOL-I; apolipoprotein L; ApoL-I; CDNA FLJ59906, Moderately Similar To apolipoprotein-L1; FSGS4; apolipoprotein L 1 Isoform 2; APO-L; apolipoprotein L 1 Isoform 1; Apo-L; Alternat
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-187769
CAS No.: 913541-44-3
Target:
Research Areas:
KD026-metabolite (compound 5) serves as a synthetic intermediate for the preparation of compounds that inhibit microsomal triglyceride transfer protein (MTP) and apolipoprotein B (Apo B) secretion. KD026-metabolite can be used to synthesize MTP and Apo B secretion inhibitors, which are applied in research on related diseases such as atherosclerosis, hypertriglyceridemia and obesity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
