48

Encorafenib

48 Publications Verification

Cat. No.: HY-15605

CAS No.: 1269440-17-6

Purity: 99.83%

Synonyms: LGX818

Target:

Raf

Research Areas:

Cancer

Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAF ^V600E (EC₅₀=4 nM).

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22

JR-AB2-011

22 Cited Publications

Cat. No.: HY-122022

CAS No.: 2411853-34-2

Purity: 98.15%

Target:

mTOR

Research Areas:

Cancer

JR-AB2-011 is a selective mTORC2 inhibitor with an IC₅₀ value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (K_i: 0.19 μM) .JR-AB2-011 decreases the phosphorylation level of Akt, decreases MMP2 activity, thereby reducing the ability of tumor cells to migrate and invade. JR-AB2-011 also induces non-apoptotic cell death .

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15

Clemastine

15 Cited Publications

Cat. No.: HY-B0298

CAS No.: 15686-51-8

Synonyms: HS-592; Meclastine

Target:

Histamine Receptor mAChR Autophagy Apoptosis Keap1-Nrf2 p62 mTOR Pyroptosis IKK

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Clemastine (HS-592; Meclastine) is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

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15

Clemastine fumarate

15 Cited Publications

Cat. No.: HY-B0298A

CAS No.: 14976-57-9

Synonyms: HS-592 fumarate; Meclastine fumarate

Target:

Histamine Receptor Apoptosis mAChR Pyroptosis Keap1-Nrf2 p62 Autophagy mTOR IKK

Research Areas:

Neurological Disease Metabolic Disease

Clemastine (HS-592; Meclastine) fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

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14

Bafetinib

14 Cited Publications

Cat. No.: HY-50868

CAS No.: 859212-16-1

Synonyms: INNO-406; NS-187

Target:

Bcr-Abl Src Apoptosis

Research Areas:

Cancer

Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph ⁺ leukemia cells. Bafetinib has antitumor activity .

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14

Ginkgolide B

14 Cited Publications

Cat. No.: HY-N0784

CAS No.: 15291-77-7

Synonyms: BN-52021

Category:

Ginkgoaceae Extract Terpenoids Ginkgo biloba L. Diterpenoids Plants Endogenous metabolite Disease Research Fields Cancer

Target:

Platelet-activating Factor Receptor (PAFR) Apoptosis

Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

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12

4,5-Dicaffeoylquinic acid

12 Cited Publications

Cat. No.: HY-N0058

CAS No.: 57378-72-0

Synonyms: Isochlorogenic acid C; 4,5-diCQA

Category:

Infection Ketones, Aldehydes, Acids Phenols Polyphenols Plants Compositae Extract Bowdichia virgilioides Endogenous metabolite Disease Research Fields

Target:

HBV Endogenous Metabolite Apoptosis Glycosidase

4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

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11

Angelicin

11 Cited Publications

Cat. No.: HY-N0763

CAS No.: 523-50-2

Synonyms: Isopsoralen

Category:

Coumarins Leguminosae Extract Psoralea corylifolia L. Phenylpropanoids Plants Disease Research Fields Cancer

Target:

Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase

Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

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10

Danshensu

10 Cited Publications

Cat. No.: HY-N1913

CAS No.: 76822-21-4

Synonyms: Dan shen suan A; Salvianic acid A

Category:

Simple Phenylpropanols Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer Labiatae Extract

Target:

Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis

Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

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10

Danshensu sodium

10 Cited Publications

Cat. No.: HY-N1913A

CAS No.: 81075-52-7

Synonyms: Dan shen suan A sodium; Salvianic acid A sodium

Category:

Simple Phenylpropanols Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants Labiatae Extract

Target:

Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

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