226 Results for "

apoptotic pathway

" in MedChemExpress (MCE) Product Catalog:
Products (226)

226 Results for "apoptotic pathway" in MCE Product Catalog:

77
ABT-737
ABT-737
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77 Publications Verification
Cat. No.: HY-50907
CAS No.: 852808-04-9
Target:  

Bcl-2 Family Apoptosis Autophagy Mitophagy

Research Areas:  

Inflammation/Immunology Cancer

ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research .
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29
Tirzepatide sodium
Tirzepatide sodium
0 Images
29 Cited Publications
Cat. No.: HY-P1731C
Synonyms: LY3298176 sodium
Target:  

GLP Receptor Insulin Receptor Apoptosis mTOR

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Tirzepatide sodium (LY3298176 sodium) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide sodium exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide sodium can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .
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20
Rolipram
Rolipram
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20 Cited Publications
Cat. No.: HY-16900
CAS No.: 61413-54-5
Synonyms: (R,S)-Rolipram; (±)-Rolipram; ZK 62711
Target:  

Bacterial HIV Phosphodiesterase (PDE) Epigenetic Reader Domain Amyloid-β

Research Areas:  

Infection Neurological Disease Cancer

Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis .
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14
Bafetinib
Bafetinib
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14 Cited Publications
Cat. No.: HY-50868
CAS No.: 859212-16-1
Synonyms: INNO-406; NS-187
Target:  

Bcr-Abl Src Apoptosis

Research Areas:  

Cancer

Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph + leukemia cells. Bafetinib has antitumor activity .
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12
Sophocarpine
Sophocarpine
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12 Cited Publications
Cat. No.: HY-N0103
CAS No.: 6483-15-4
Category:  

Infection Alkaloids Piperidine Alkaloids 500 - Internal Server Error | MedChemExpress

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