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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
arenes
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "arenes" in MCE Product Catalog:
Cat. No.: HY-I0101
CAS No.: 60705-62-6
Synonyms: Tetra-tert-butyl(tetrahydroxy)calix[4]arene
Target:
Research Areas:
4-tert-Butylcalix[4]arene (Tetra-tert-butyl(tetrahydroxy)calix[4]arene) is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-19094
CAS No.: 124750-95-4
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DuP-532 is an angiotensin type 1 receptor antagonist with potential activity in the suppression of hypertension and heart failure. DuP-532 can react with a range of aryl and heteroaryl halides to form perfluoroalkyl(hetero)arenes in moderate to high yields. Computational studies of DuP-532 suggest that coordination of a second phenyl ring ligand may lower the energy barrier for decarboxylation of perfluorocarboxylates, thereby promoting the perfluoroalkylation reaction .
Cat. No.: HY-W440555
CAS No.: 112269-92-8
Synonyms: para-Sulfonatocalix[n]arene
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4-Sulfocalix[4]arene (para-Sulfonatocalix[n]arene) is a amyloid-beta 42 binder with a Kd of 5.39 M. 4-Sulfocalix[4]arene can inhibit amyloid β-peptide fibrillation and reduce amyloid cytotoxicity .
Cat. No.: HY-W440556
CAS No.: 137407-62-6
Synonyms: 4-Sulfocalix[8]arene
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Research Areas:
GL-522 (4-Sulfocalix[8]arene) is a Aβ42 inhibitor. GL-522 bind to Aβ42 through nonspecific and multipoint hydrophobic interactions with a Kd of 276 μM. GL-522 effectively inhibits Aβ42 fibrillation and reduces amyloid cytotoxicity. GL-522 can be used for Alzheimer's disease research .
Cat. No.: HY-12491
CAS No.: 691388-62-2
PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma .
Cat. No.: HY-189131
CAS No.: 1628717-55-4
Synonyms: CTT-1057
Vidoflufolastat (CTT-1057) is a PSMA inhibitor with an IC50 of 0.4 nM. Vidoflufolastat binds irreversibly to the active-site zinc ion through its phosphoramidate core, while its distal fluorobenzoyl ring interacts with the arene-binding site. Vidoflufolastat can be used in research on prostate cancer and Pseudomonas aeruginosa infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
