2527 Results for "

arrest,

" in MedChemExpress (MCE) Product Catalog:
Products (2527)

2527 Results for "arrest," in MCE Product Catalog:

513
MK-2206
MK-2206
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513 Publications Verification
Cat. No.: HY-108232
CAS No.: 1032349-77-1
Purity:  99.72%
Target:  

Bcl-2 Family Apoptosis mTOR Akt GSK-3

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

MK-2206 is an orally active pan-AKT inhibitor, with IC50 values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 induces G1-phase cell cycle arrest, apoptosis, epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia .
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513
MK-2206 dihydrochloride
MK-2206 dihydrochloride
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513 Publications Verification
Cat. No.: HY-10358
CAS No.: 1032350-13-2
Purity:  99.94%
Synonyms: MK-2206 (2HCl)
Target:  

Bcl-2 Family Apoptosis mTOR Akt GSK-3

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

MK-2206 dihydrochloride (MK-2206 2HCl) is an orally active pan-AKT inhibitor, with IC50 values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 dihydrochloride inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 dihydrochloride induces G1-phase cell cycle arrest, apoptosis, epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 dihydrochloride causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 dihydrochloride can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia .
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414
Paclitaxel
Paclitaxel
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414 Cited Publications
Cat. No.: HY-B0015
CAS No.: 33069-62-4
Category:  

Taxaceae Extract Terpenoids Diterpenoids Plants Disease Research Fields Cancer 500 - Internal Server Error | MedChemExpress

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