47 Results for "

arthritic

" in MedChemExpress (MCE) Product Catalog:
Products (47)

47 Results for "arthritic" in MCE Product Catalog:

9
9 Publications Verification
Cat. No.: HY-N0705
CAS No.: 85643-19-2
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .
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3
3 Cited Publications
Cat. No.: HY-N2513
CAS No.: 631-69-6
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC50 values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases .
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3
3 Cited Publications
Cat. No.: HY-12511
CAS No.: 72873-74-6
Purity:  99.91%
Target:  

p38 MAPK

Research Areas:  

Inflammation/Immunology

SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .
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2
2 Cited Publications
Cat. No.: HY-B1456A
CAS No.: 29679-58-1
Synonyms: LILLY-53858
Research Areas:  

Inflammation/Immunology

Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
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2
2 Cited Publications
Cat. No.: HY-N6647
CAS No.: 20633-84-5
Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
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2
2 Cited Publications
Cat. No.: HY-111149A
CAS No.: 1596362-29-6
Purity:  95.03%
Target:  

CXCR

Research Areas:  

Inflammation/Immunology

PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation .
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2
2 Cited Publications
Cat. No.: HY-B0288B
CAS No.: 71720-56-4
Synonyms: LILLY-53858 Calcium hydrate
Research Areas:  

Inflammation/Immunology

Fenoprofen (LILLY-53858) Calcium hydrate is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium hydrate is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium hydrate also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium hydrate has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
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1
1 Cited Publications
Cat. No.: HY-108065A
CAS No.: 128596-80-5
Purity:  ≥98.0%
Synonyms: 3'-SL sodium
3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .
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1
1 Cited Publications
Cat. No.: HY-N4136
CAS No.: 25694-72-8
Synonyms: Veronicastroside
Lonicerin (Veronicastroside) is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC50 of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties .
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1
1 Cited Publications
Cat. No.: HY-P0107A
CAS No.: 1217463-61-0
Target:  

Bombesin Receptor

Research Areas:  

Inflammation/Immunology

RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice .
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1
1 Cited Publications
Cat. No.: HY-P0107
CAS No.: 138147-78-1
Target:  

Bombesin Receptor

Research Areas:  

Inflammation/Immunology

RC-3095 is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 exerts protective effects by reducing gastric oxidative injury in the arthritic mice .
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Cat. No.: HY-129566
CAS No.: 56973-41-2
Purity:  98.52%
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .
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Cat. No.: HY-108065
CAS No.: 35890-38-1
Synonyms: 3'-SL
3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .
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Cat. No.: HY-136540
CAS No.: 916888-47-6
Synonyms: RvD3
Target:  

AMPK Autophagy

Research Areas:  

Inflammation/Immunology

Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .
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Cat. No.: HY-111149
CAS No.: 914291-61-5
Target:  

CXCR

Research Areas:  

Inflammation/Immunology

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation .
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Cat. No.: HY-B0288A
CAS No.: 34597-40-5
Synonyms: LILLY-53858 Calcium
Research Areas:  

Inflammation/Immunology

Fenoprofen (LILLY-53858) Calcium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
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Cat. No.: HY-145491
CAS No.: 578008-43-2
Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis .
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Cat. No.: HY-107360
CAS No.: 64808-48-6
Purity:  99.94%
Synonyms: CCA
Lobenzarit disodium (CCA) is an anti-arthritic and anti-oxidative agent .
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Cat. No.: HY-120529
CAS No.: 134044-97-6
Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis.
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Cat. No.: HY-18759
CAS No.: 948842-66-8
Target:  

p38 MAPK TNF Receptor

Research Areas:  

Inflammation/Immunology

BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA). BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model .
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