3 Results for "

autophagy-lysosomal function

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "autophagy-lysosomal function" in MCE Product Catalog:

1
ARL 17477
ARL 17477
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1 Cited Publications
Cat. No.: HY-107720
CAS No.: 866914-87-6
Purity:  99.02%
Target:  

NO Synthase Autophagy PERK

ARL 17477 is a blood-brain barrier-penetrant selective neuronal nitric oxide synthase (nNOS) inhibitor with an IC50 of 1 μM. ARL 17477 reduces nitric oxide production and activates TFEB and lysosomal biogenesis, induces lysosomal membrane permeabilization, but inhibits autophagy-lysosomal function, autophagic flux, protein aggregate clearance, and proliferation. ARL 17477 induces ERK hyperphosphorylation and slight AKT inhibition. ARL 17477 exhibits NOS1 -independent anticancer activity against multiple cancer cells. ARL 17477 inhibits xenograft tumor growth in vivo. ARL 17477 can be used in research on colon cancer, non-small cell lung cancer, osteosarcoma, pancreatic cancer, arterial occlusion, and pain .
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Tetrahydroalstonine
Tetrahydroalstonine
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Cat. No.: HY-N1163
CAS No.: 6474-90-4
Synonyms: (-)-Tetrahydroalstonine
Category:  

Alkaloids Plants Indole Alkaloids Apocynaceae Extract 500 - Internal Server Error | MedChemExpress

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