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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
bacterial HSP90
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "bacterial HSP90" in MCE Product Catalog:
Cat. No.: HY-15990
CAS No.: 1052645-73-4
CH5164840 is an orally active HSP90α/β inhibitor with Kd values of 0.52 and 1.4 nM, respectively. CH5164840 degrades client proteins such as HER2/HER3/EGFR and inhibits the PI3K/AKT and RAF/MEK/ERK pathways, inducing HSP70 and apoptosis (apoptosis). CH5164840 causes spindle dysfunction and centromere-positive micronuclei, without kinase inhibition or mutagenicity. CH5164840 exhibits antitumor efficacy in vivo and acts synergistically with Trastuzumab (HY-P9907) and Lapatinib (HY-50898). CH5164840 shows no significant bacterial mutagenicity. CH5164840 can be used in research related to gastric cancer, breast cancer, ovarian cancer, prostate cancer, and colorectal cancer .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
