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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
bacterial SOS response
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "bacterial SOS response" in MCE Product Catalog:
Cat. No.: HY-162959
CAS No.: 2254567-00-3
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BWC0977 acts as an inhibitor of bacterial Topoisomerase. BWC0977 stabilizes single-strand DNA breaks, inhibits DNA supercoiling and decatenation activities, binds to GyrA and ParC residues, and activates the SOS response. BWC0977 can be used in research related to multidrug-resistant bacterial infections .
Cat. No.: HY-U00035
CAS No.: 1000277-08-6
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MGB-BP-3 is an orally aective Gram-positive bactericide and DNA-binding agent. MGB-BP-3 blocks transcription initiation by binding to AT-rich bacterial DNA regions, and interferes with the functions of DNA gyrase and topoisomerase IV, but does not stabilize cleavage complexes or induce the SOS response. MGB-BP-3 induces energy depletion in *Staphylococcus aureus* and inhibits spore formation in *Clostridioides difficile*, exhibiting intrinsic resistance resilience. MGB-BP-3 can be used in the research of *Clostridioides difficile*-associated diseases .
Cat. No.: HY-162959A
CAS No.: 3027162-72-4
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BWC0977 formic acts as an inhibitor of bacterial Topoisomerase. BWC0977 formic stabilizes single-strand DNA breaks, inhibits DNA supercoiling and decatenation activities, binds to GyrA and ParC residues, and activates the SOS response. BWC0977 formic can be used in research related to multidrug-resistant bacterial infections .
Cat. No.: HY-U00035R
CAS No.: 1000277-08-6
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MGB-BP-3 (Standard) is the analytical standard of MGB-BP-3 (HY-U00035). This product is intended for research and analytical applications. MGB-BP-3 is an orally aective Gram-positive bactericide and DNA-binding agent. MGB-BP-3 blocks transcription initiation by binding to AT-rich bacterial DNA regions, and interferes with the functions of DNA gyrase and topoisomerase IV, but does not stabilize cleavage complexes or induce the SOS response. MGB-BP-3 induces energy depletion in *Staphylococcus aureus* and inhibits spore formation in *Clostridioides difficile*, exhibiting intrinsic resistance resilience. MGB-BP-3 can be used in the research of *Clostridioides difficile*-associated diseases .
Cat. No.: HY-126258
CAS No.: 1458674-25-3
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IMP-1700 is a potent DNA damage potentiator and antibacterial agent. IMP-1700 inhibits the bacterial SOS response to DNA damage. IMP-1700 potently sensitizes MRSA to Ciprofloxacin (HY-B0356) with an EC50 of 5.9 nM. IMP-1700 inhibits the growth of E. coli K-12 BW25113, S. aureus SH1000 and MRSA USA300 JE2 .
Cat. No.: HY-189704
CAS No.: 3088774-28-8
IMP-2380 is a NorA inhibitor that binds to the outward-open conformation of Staphylococcus aureus NorA. IMP-2380 enhances the activity of Ciprofloxacin against Methicillin-resistant (HY-121544) and Methicillin-sensitive Staphylococcus aureus. IMP-2380 inhibits Ciprofloxacin-induced SOS response and reduces prophage induction. IMP-2380 reduces bacterial burden in a mouse MRSA infection model in combination with Ciprofloxacin. IMP-2380 can be used for research on Methicillin-resistant Staphylococcus aureus (MRSA) infection .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
