258 Results for "

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" in MedChemExpress (MCE) Product Catalog:
Products (258)

258 Results for "bearing" in MCE Product Catalog:

38
C188-9
C188-9
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38 Publications Verification
Cat. No.: HY-112288
CAS No.: 432001-19-9
Purity:  99.90%
Synonyms: TTI-101
Target:  

STAT Apoptosis DNA Methyltransferase

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

C188-9 (TTI-101) is a STAT3 inhibitor with a Kd value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .
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8
Tryptanthrin
Tryptanthrin
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8 Cited Publications
Cat. No.: HY-N6607
CAS No.: 13220-57-0
Category:  

Alkaloids Plants Disease Research Fields Inflammation/Immunology 500 - Internal Server Error | MedChemExpress

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