154

Etomoxir

154 Publications Verification

Cat. No.: HY-50202

CAS No.: 124083-20-1

Synonyms: (R)-(+)-Etomoxir

Target:

Carnitine Palmitoyltransferase (CPT) Apoptosis

Research Areas:

Metabolic Disease Cancer

Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

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154

Etomoxir sodium salt

154 Publications Verification

Cat. No.: HY-50202A

CAS No.: 828934-41-4

Synonyms: (R)-(+)-Etomoxir sodium salt

Target:

Carnitine Palmitoyltransferase (CPT) Apoptosis

Research Areas:

Metabolic Disease Cancer

Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .

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22

L-Carnitine

22 Cited Publications

Cat. No.: HY-B0399

CAS No.: 541-15-1

Synonyms: (R)-Carnitine; Levocarnitine

Category:

Natural Products Neurological Disease Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Nervous System Disorder Disease Research Fields Cancer

Target:

Endogenous Metabolite

L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .

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22

L-Carnitine hydrochloride

22 Cited Publications

Cat. No.: HY-B2246

CAS No.: 6645-46-1

Synonyms: (R)-Carnitine hydrochloride; Levocarnitine hydrochloride

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .

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22

L-Carnitine tartrate

22 Cited Publications

Cat. No.: HY-W105518

CAS No.: 36687-82-8

L-Carnitine tartrate is a highly polar, small zwitterion. L-Carnitine tartrate is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine tartrate functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine tartrate is an antioxidant. L-Carnitine tartrate can ameliorate metabolic imbalances in many inborn errors of metabolism ^{[3] ^.}

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20

Trimetazidine

20 Cited Publications

Cat. No.: HY-B0968A

CAS No.: 5011-34-7

Target:

Autophagy

Research Areas:

Cardiovascular Disease

Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC₅₀ of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .

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20

Trimetazidine dihydrochloride

20 Cited Publications

Cat. No.: HY-B0968

CAS No.: 13171-25-0

Target:

Autophagy

Research Areas:

Cardiovascular Disease

Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC₅₀ of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor .

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11

NADH disodium salt

11 Cited Publications

Cat. No.: HY-F0001

CAS No.: 606-68-8

Synonyms: Disodium NADH

Category:

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Calcium Channel VDAC

NADH disodium salt (Disodium NADH) is an orally effective reduced coenzyme. NADH disodium salt plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. NADH disodium salt regulates calcium homeostasis by promoting the opening of IP3-gated Ca ²⁺ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. NADH disodium salt is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction .

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