61 Results for "

bile acids

" in MedChemExpress (MCE) Product Catalog:
Products (61)

61 Results for "bile acids" in MCE Product Catalog:

4
CP-724714
CP-724714
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4 Cited Publications
Cat. No.: HY-14674
CAS No.: 383432-38-0
Purity:  98.72%
Target:  

EGFR Apoptosis P-glycoprotein Raf ERK

Research Areas:  

Infection Cancer

CP-724714 is an orally active and selective HER2 tyrosine kinase inhibitor with an IC50 of 10 nM. CP-724714 inhibits HER2 receptor autophosphorylation and blocks the downstream Ras-Raf-Mek-Erk signaling pathway, thereby inducing cell cycle arrest and apoptosis in tumor cells. CP-724714 exhibits antiviral activity and inhibits various porcine diarrheal coronaviruses, including SADS-CoV (IC50 of 0.91 μM). CP-724714 is an inhibitor of the hepatic transport receptors OATP1B1/MDR1/BSEP, and can enter hepatocytes via active uptake and trigger the accumulation of drugs and bile acids within hepatocytes. CP-724714 can be used in research related to HER2-overexpressing breast cancer and porcine diarrheal coronavirus infection .
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7-keto-Deoxycholic acid
7-keto-Deoxycholic acid
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2 Cited Publications
Cat. No.: HY-41324
CAS No.: 911-40-0
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Drug Metabolite

7-keto-Deoxycholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-Deoxycholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition .
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Sevelamer hydrochloride
Sevelamer hydrochloride
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1 Cited Publications
Cat. No.: HY-13995A
CAS No.: 152751-57-0
Purity:  ≥98.0%
Target:  

FXR

Research Areas:  

Metabolic Disease Endocrinology

Sevelamer hydrochloride is an orally active polymeric phosphate binder and bile acid sequestrant. Sevelamer hydrochloride binds dietary phosphate in the gastrointestinal tract, reducing phosphate absorption and serum phosphorus levels, and reduces urinary phosphate excretion. Sevelamer hydrochloride binds polyanion bile acids, increases bile acid faecal excretion, and reduces total cholesterol and LDL cholesterol levels. Sevelamer hydrochloride can be used for the research of hyperphosphataemia, hyperparathyroidism, chronic renal failure, kidney disease, and type 2 diabetes .
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Rebaudioside D
Rebaudioside D
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1 Cited Publications
Cat. No.: HY-N0468
CAS No.: 63279-13-0
Category:  

Terpenoids Metabolic Disease Diterpenoids Plants Other Families Extract Disease Research Fields Sweeteners Food Research

Target:  

FXR Acetyl-CoA Carboxylase

Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .
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Sevelamer carbonate
Sevelamer carbonate
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1 Cited Publications
Cat. No.: HY-13995B
CAS No.: 845273-93-0
Target:  

FXR

Research Areas:  

Metabolic Disease Endocrinology

Sevelamer carbonate is an orally active polymeric phosphate binder and bile acid sequestrant. Sevelamer carbonate binds dietary phosphate in the gastrointestinal tract, reducing phosphate absorption and serum phosphorus levels, and reduces urinary phosphate excretion. Sevelamer carbonate binds polyanion bile acids, increases bile acid faecal excretion, and reduces total cholesterol and LDL cholesterol levels. Sevelamer carbonate can be used for the research of hyperphosphataemia, hyperparathyroidism, chronic renal failure, kidney disease, and type 2 diabetes .
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Isodeoxycholic acid
Isodeoxycholic acid
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1 Cited Publications
Cat. No.: HY-W399297
CAS No.: 566-17-6
Synonyms: 7α,12α-Dihydroxycholanoic acid
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite

Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) is a 3β-hydroxylated secondary bile acid. Isodeoxycholic acid is produced by epimerization of deoxycholic acid by intestinal bacteria. Isodeoxycholic acid is detectable in feces, mainly existing as saponifiable conjugates with long-chain fatty acids. Isodeoxycholic acid participates in the regulation of intestinal physiology .
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4β-Hydroxycholesterol
4β-Hydroxycholesterol
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Cat. No.: HY-124265
CAS No.: 17320-10-4
Purity:  99.96%
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite

4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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Isethionic acid (80% in water)
Isethionic acid (80% in water)
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Cat. No.: HY-Y0095
CAS No.: 107-36-8
Synonyms: 2-Hydroxyethanesulfonic acid
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Marine natural products Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Parasite

Isethionic acid (2-Hydroxyethanesulfonic acid) is an endogenous mammalian Taurine (HY-B0351) metabolite. Isethionic acid forms covalent ester linkages with cholic acid. It acts as a larval settlement inhibitor for Balanus amphitrite with larval toxicity. Isethionic acid enables the low-temperature synthesis of highly hygroscopic water-soluble sulfonates, and its acylated derivatives serve as acidic wetting solubilizers. It is used in studies related to hepatic bile acid metabolism, biological control and organic synthesis .
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Bile extract
Bile extract
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Cat. No.: HY-N8332
CAS No.: 8008-63-7
Synonyms: Ox bile extract
Bile extract (Ox bile extract) is a complex mixture of substances, containing bile acids, cholesterol, and bilirubin. Bile extract has antimicrobial activity and can induce DNA damage and degrade viral and bacterial membranes. Bile extract can be used in bacterial culture media as a selective inhibitor for the isolation and identification of pathogens .
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6-Oxolithocholic acid
6-Oxolithocholic acid
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Cat. No.: HY-W587530
CAS No.: 2393-61-5
Synonyms: 6-Ketolithocholic acid
Target:  

Endogenous Metabolite Apoptosis

Research Areas:  

Endocrinology

6-Oxolithocholic acid is a bile acid metabolite derived from Lithocholic acid (HY-B0172). 6-Oxolithocholic acid has high cytotoxicity and can induce apoptosis, especially in hepatocytes. 6-Oxolithocholic acid can participate in the regulation of bile acid metabolism and synthesis and affect the metabolic pathway of cholesterol. 6-Oxolithocholic acid can be used to study the role of bile acids in health and disease, especially in the context of digestive and liver diseases .
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Colesevelam hydrochloride
Colesevelam hydrochloride
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Cat. No.: HY-106539
CAS No.: 182815-44-7
Purity:  ≥95.0%
Target:  

FXR G protein-coupled Bile Acid Receptor 1 GLP Receptor

Research Areas:  

Metabolic Disease Cancer

Colesevelam hydrochloride is an orally active bile acid sequestrant, lipid-lowering agent, and glycemic control agent. Colesevelam hydrochloride binds bile acids in the gastrointestinal tract to form nonabsorbable complexes, interrupts enterohepatic recirculation and increases fecal bile acid elimination. Colesevelam hydrochloride modulates FXR, TGR5, and Cyp7a1 activity and triggers cAMP signaling and GLP-1 release. Colesevelam hydrochloride alters hepatic lipid and glucose metabolism, suppresses hepatic glycogenolysis, reduces hepatic triglyceride and cholesterol levels, and increases LDL-C (low-density lipoprotein cholesterol) clearance. Colesevelam hydrochloride can be used for the research of type 2 diabetes mellitus, hypercholesterolemia, and alcohol-related liver disease .
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Cholesterol 5α,6α-epoxide
Cholesterol 5α,6α-epoxide
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Cat. No.: HY-133971
CAS No.: 1250-95-9
Purity:  98.40%
Synonyms: 5α,6α-Epoxycholesterol
Target:  

Liposome

Research Areas:  

Others

Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.
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Apocholic acid
Apocholic acid
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Cat. No.: HY-W747583
CAS No.: 641-81-6
Category:  

Endogenous metabolite Steroids

Target:  

Endogenous Metabolite

Apocholic acid is a bile acid belonging to steroidal organic acids. Apocholic acid is an endogenous metabolite .
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4β-Hydroxycholesterol-d7
4β-Hydroxycholesterol-d7
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Cat. No.: HY-124265S
CAS No.: 1246302-80-6
Purity:  99.70%
4β-Hydroxycholesterol-d7 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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7α-Hydroxy-4-cholesten-3-one
7α-Hydroxy-4-cholesten-3-one
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Cat. No.: HY-113259
CAS No.: 3862-25-7
Purity:  99.60%
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite

7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 .
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Arabinoxylan (Medium viscosity)
Arabinoxylan (Medium viscosity)
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Cat. No.: HY-N15135
CAS No.: 9040-27-1
Category:  

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