1011 Results for "

bioavailable

" in MedChemExpress (MCE) Product Catalog:

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269

Venetoclax

269 Publications Verification

Cat. No.: HY-15531

CAS No.: 1257044-40-8

Purity: 99.95%

Synonyms: ABT-199; GDC-0199; RG7601

Target:

Bcl-2 Family Autophagy

Research Areas:

Cancer

Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy .

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135

Imatinib

135 Cited Publications

Cat. No.: HY-15463

CAS No.: 152459-95-5

Purity: 99.95%

Synonyms: STI571; CGP-57148B

Target:

Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy

Research Areas:

Cancer

Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and MERS-CoV .

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130

Sotorasib

130 Cited Publications

Cat. No.: HY-114277

CAS No.: 2296729-00-3

Purity: 99.94%

Synonyms: AMG-510

Target:

Ras

Research Areas:

Cancer

Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C‑mutated locally advanced or metastatic non‑small cell lung cancer (NSCLC) .

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Crizotinib

92 Cited Publications

Cat. No.: HY-50878

CAS No.: 877399-52-5

Synonyms: PF-02341066

Target:

Ligands for Target Protein for PROTAC Anaplastic lymphoma kinase (ALK) c-Met/HGFR ROS Kinase

Research Areas:

Cancer

Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition .

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Crizotinib hydrochloride

92 Cited Publications

Cat. No.: HY-50878A

CAS No.: 1415560-69-8

Synonyms: PF-02341066 hydrochloride

Target:

Anaplastic lymphoma kinase (ALK) c-Met/HGFR ROS Kinase Autophagy

Research Areas:

Cancer

Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition .

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Niraparib tosylate

91 Cited Publications

Cat. No.: HY-10619B

CAS No.: 1038915-73-9

Purity: 99.99%

Synonyms: MK-4827 tosylate

Target:

PARP Apoptosis

Research Areas:

Cancer

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC₅₀ of 3.8 and 2.1 nM, respectively. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity .

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Niraparib

91 Cited Publications

Cat. No.: HY-10619

CAS No.: 1038915-60-4

Purity: 99.96%

Synonyms: MK-4827

Target:

PARP Apoptosis

Research Areas:

Cancer

Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC₅₀s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity .

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Niraparib hydrochloride

91 Cited Publications

Cat. No.: HY-10619A

CAS No.: 1038915-64-8

Purity: 99.41%

Synonyms: MK-4827 hydrochloride

Target:

PARP Apoptosis

Research Areas:

Cancer

Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC₅₀s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity .

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Niraparib tosylate hydrate

90 Cited Publications

Cat. No.: HY-10619E

CAS No.: 1613220-15-7

Purity: 99.97%

Synonyms: MK-4827 tosylate hydrate

Target:

PARP Apoptosis

Research Areas:

Cancer

Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC₅₀s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity .

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Baricitinib

87 Cited Publications

Cat. No.: HY-15315

CAS No.: 1187594-09-7

Purity: 99.93%

Synonyms: LY3009104; INCB028050

Target:

JAK

Research Areas:

Inflammation/Immunology

Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC₅₀s of 5.9 nM and 5.7 nM, respectively.

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Baricitinib phosphate

87 Cited Publications

Cat. No.: HY-15315A

CAS No.: 1187595-84-1

Purity: 99.97%

Synonyms: LY3009104 phosphate; INCB028050 phosphate

Target:

JAK

Research Areas:

Inflammation/Immunology

Baricitinib phosphate (LY3009104 phosphate; INCB028050 phosphate) is a selective orally bioavailable JAK1/JAK2 inhibitor with IC₅₀ of 5.9 nM and 5.7 nM, respectively.

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