110

FITC

110 Publications Verification

Cat. No.: HY-66019

CAS No.: 3326-32-7

Synonyms: Fluorescein 5-isothiocyanate

Target:

Fluorescent Dye

Research Areas:

Others

FITC (Fluorescein Isothiocyanate), is one of the green fluorescein derivatives widely used in biology. FITC has the characteristics of high absorptivity and excellent fluorescence quantum yield. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. In addition to its use as a protein marker, FITC can also be used as a fluorescent protein tracer to rapidly identify pathogens by labeling antibodies, or for microsequencing of proteins and peptides (HPLC). The maximum excitation wavelength of FITC is 494 nm. Once excited, it fluoresces yellow-green at a maximum emission wavelength of 520 nm. In addition, FITC is also a hapten that can induce contact hypersensitivity (CHS) and induce an atopic dermatitis model .

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50

Rifampicin

50 Cited Publications

Cat. No.: HY-B0272

CAS No.: 13292-46-1

Synonyms: Rifampin; Rifamycin AMP

Target:

Bacterial Influenza Virus Antibiotic Orthopoxvirus

Research Areas:

Infection Cancer

Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity.

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34

Amphotericin B

34 Cited Publications

Cat. No.: HY-B0221

CAS No.: 1397-89-3

Category:

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields

Target:

Fungal Antibiotic Bacterial Parasite

Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

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18

Ruthenium red

18 Cited Publications

Cat. No.: HY-103311

CAS No.: 11103-72-3

Purity: ≥97.0%

Synonyms: Ammoniated ruthenium oxychloride

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease

Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (I_Ca) blocker. When using Ruthenium Red to stain plant tissue sections affected by pathogens, the breakdown of mucilaginous substances by the pathogens prevents them from taking up the stain, whereas the cell walls of healthy tissue stain red .

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15

Oxacillin sodium salt

15 Cited Publications

Cat. No.: HY-B0925

CAS No.: 1173-88-2

Target:

Bacterial Antibiotic

Research Areas:

Infection

Oxacillin sodium salt is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens .

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13

Galidesivir hydrochloride

13 Cited Publications

Cat. No.: HY-18649

CAS No.: 222631-44-9

Synonyms: BCX4430 hydrochloride; Immucillin-A hydrochloride

Target:

DNA/RNA Synthesis SARS-CoV Filovirus

Research Areas:

Infection

Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC₅₀s ranging from ~3 to ~68 μM .

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13

Galidesivir

13 Cited Publications

Cat. No.: HY-18649A

CAS No.: 249503-25-1

Synonyms: BCX4430; Immucillin-A

Target:

DNA/RNA Synthesis SARS-CoV Filovirus

Research Areas:

Infection

Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC₅₀s ranging from ~3 to ~68 μM .

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8

Lysozyme

8 Cited Publications

Cat. No.: HY-P1068

CAS No.: 9001-63-2

Synonyms: Muramidase

Target:

Bacterial TNF Receptor Interleukin Related TGF-β Receptor

Research Areas:

Infection Inflammation/Immunology

Lysozyme (Muramidase) is a conserved antimicrobial protein. Lysozyme exerts its bactericidal effect by hydrolyzing bacterial cell wall peptidoglycan (PG). Lysozyme plays an important role in limiting bacterial growth on mucosal surfaces and other sites, not only controlling potential pathogens but also limiting overgrowth of microbiota to prevent dysbiosis. Extracellular lysozyme can also degrade polymeric PG into soluble fragments, activate NOD receptors in mucosal epithelial cells, and lead to the secretion of chemokines and activating factors by neutrophils and macrophages .

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7

Sitafloxacin hydrate

7 Cited Publications

Cat. No.: HY-B0395C

CAS No.: 163253-35-8

Synonyms: DU6859a hydrate

Target:

Bacterial Antibiotic

Research Areas:

Infection

Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic (antibiotic) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections .

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7

L-Isoleucine

7 Cited Publications

Cat. No.: HY-N0771

CAS No.: 73-32-5

Category:

Endocrine diseases Amino acids Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Other Diseases Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder

Target:

Endogenous Metabolite

L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

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7

Sitafloxacin

7 Cited Publications

Cat. No.: HY-B0395

CAS No.: 127254-12-0

Synonyms: DU6859a

Target:

Bacterial Antibiotic

Research Areas:

Infection

Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection .

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7

Tat-beclin 1

7 Cited Publications

Cat. No.: HY-P2260

CAS No.: 1423821-88-8

Target:

CHIKV Autophagy HIV

Research Areas:

Infection

Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

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6

Enmetazobactam

6 Cited Publications

Cat. No.: HY-103095

CAS No.: 1001404-83-6

Purity: 98.25%

Synonyms: AAI101

Target:

Beta-lactamase Bacterial

Research Areas:

Infection

Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens .

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6

N-Hydroxypipecolic acid

6 Cited Publications

Cat. No.: HY-N7378

CAS No.: 115819-92-6

Synonyms: 1-Hydroxy-2-piperidinecarboxylic acid; NHP

Category:

Ketones, Aldehydes, Acids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:

Bacterial

N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection .

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5

Alexidine dihydrochloride

5 Cited Publications

Cat. No.: HY-108547

CAS No.: 1715-30-6

Purity: 99.68%

Target:

Fungal Apoptosis

Research Areas:

Infection Cancer

Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens .

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5

Cephradine

5 Cited Publications

Cat. No.: HY-B1156

CAS No.: 38821-53-3

Synonyms: Cefradine; SQ-11436

Target:

Bacterial Antibiotic TOPK

Research Areas:

Infection Inflammation/Immunology

Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .

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5

Cephradine monohydrate

5 Cited Publications

Cat. No.: HY-128449

CAS No.: 75975-70-1

Purity: 91.53%

Synonyms: Cefradine monohydrate

Target:

Bacterial Antibiotic TOPK

Research Areas:

Infection Inflammation/Immunology

Cephradine (Cefradine) monohydrate is a broad-spectrum and orally active cephalosporin. Cephradine monohydrate is active against both grampositive and gram-negative pathogens and effective in eradicating most penicillinase-producing organisms known to be resistant to penicillin G, penicillin V, and ampicillin. Cephradine monohydrate has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine monohydrate blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK .

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3

Trans-Cinnamic acid

3 Cited Publications

Cat. No.: HY-N0610

CAS No.: 140-10-3

Synonyms: Trans-3-Phenylacrylic acid

Category:

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