10838 Results for "

biogenesis gene ISCU

" in MedChemExpress (MCE) Product Catalog:

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274

GW4869

274 Publications Verification

Cat. No.: HY-19363

CAS No.: 6823-69-4

Target:

Exosomes Phospholipase

Research Areas:

Cardiovascular Disease Inflammation/Immunology

GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC₅₀ of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release .

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202

Doxycycline monohydrate

202 Cited Publications

Cat. No.: HY-W008923

CAS No.: 17086-28-1

Target:

MMP Parasite Bacterial Antibiotic Apoptosis Akt PI3K

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline monohydrate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline monohydrate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline monohydrate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline monohydrate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline monohydrate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline monohydrate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

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172

ATP disodium salt, 100 mM Solution, PCR Grade

172 Cited Publications

Cat. No.: HY-B2176I

CAS No.: 987-65-5

Synonyms: Adenosine 5'-triphosphate disodium salt, 100 mM Solution, PCR Grade

ATP (Adenosine 5'-triphosphate) disodium salt, 100 mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100 mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100 mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100 mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100 mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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153

D-Luciferin sodium

153 Cited Publications

Cat. No.: HY-12591

CAS No.: 103404-75-7

Purity: 99.92%

Synonyms: D-(-)-Luciferin sodium; Firefly luciferin sodium; Beetle Luciferin sodium

D-luciferin sodium is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We of er the firefly luciferase (HY-P1004A), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .

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153

D-Luciferin

153 Cited Publications

Cat. No.: HY-12591A

CAS No.: 2591-17-5

Purity: 99.54%

Synonyms: D-(-)-Luciferin; Firefly luciferin; Beetle Luciferin

Category:

Natural Products Animal Other Diseases Disease Research Fields

Target:

Fluorescent Dye

D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We of er the firefly luciferase (HY-P1004A), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .

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153

D-Luciferin potassium

153 Cited Publications

Cat. No.: HY-12591B

CAS No.: 115144-35-9

Purity: 99.97%

Synonyms: D-(-)-Luciferin potassium; Firefly luciferin potassium; Beetle Luciferin potassium

D-luciferin potassium is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We offer the firefly luciferase (HY-P1004A), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .

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122

Hexadimethrine bromide

122 Cited Publications

Cat. No.: HY-112735

CAS No.: 28728-55-4

Purity: 99.69%

Synonyms: Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide

Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer .

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2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt

95 Cited Publications

Cat. No.: HY-12885A

CAS No.: 1638750-95-4

Purity: 99.43%

Synonyms: ADU-S100 disodium salt; MIW815 disodium salt; ML RR-S2 CDA disodium salt

Target:

STING

Research Areas:

Inflammation/Immunology Cancer

2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).

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Dipotassium glycyrrhizinate

68 Cited Publications

Cat. No.: HY-N0184A

CAS No.: 68797-35-3

Synonyms: Glycyrrhizic acid dipotassium; Dipotassium glycyrrhizate

Category:

Leguminosae/Fabaceae Extract Triterpenes Plant Terpenoids Glycyrrhiza uralensis Fisch. Extract Disease Research Fields Inflammation/Immunology

Target:

Virus Protease

Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity .

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10058-F4

63 Cited Publications

Cat. No.: HY-12702

CAS No.: 403811-55-2

Purity: 99.49%

Target:

c-Myc Autophagy

Research Areas:

Cancer

10058-F4 is a c-Myc inhibitor that prevents c-Myc-Max dimerization and transactivation of c-Myc target gene expression.

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diABZI STING agonist-1 trihydrochloride

54 Cited Publications

Cat. No.: HY-112921B

CAS No.: 2138299-34-8

Purity: 99.84%

Target:

STING

Research Areas:

Inflammation/Immunology Cancer

diABZI STING agonist-1 trihydrochloride is a selective stimulator of interferon genes (STING) receptor agonist.

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IPTG

45 Cited Publications

Cat. No.: HY-15921

CAS No.: 367-93-1

Synonyms: Isopropyl β-D-thiogalactoside

IPTG is a molecular mimic of allolactose, a lactose metabolite that triggers transcription of the lac operon, and it is therefore used to induce protein expression where the gene is under the control of the lac operator.

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GLPG0187

19 Cited Publications

Cat. No.: HY-100506

CAS No.: 1320346-97-1

Purity: 99.43%

Target:

Integrin

Research Areas:

Cancer

GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits α_vβ₁-integrin with an IC₅₀ of 1.3 nM . GLPG0187 inhibits migrasome biogenesis without cytotoxicity .

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HEPES

12 Cited Publications

Cat. No.: HY-D0857

CAS No.: 7365-45-9

Target:

Biochemical Assay Reagents

Research Areas:

Others

HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis .

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HEPES sodium

12 Cited Publications

Cat. No.: HY-108535

CAS No.: 75277-39-3

Purity: 99.88%

HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis .

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Zotatifin

12 Cited Publications

Cat. No.: HY-112163

CAS No.: 2098191-53-6

Purity: 99.69%

Synonyms: eFT226

Target:

Eukaryotic Initiation Factor (eIF) SARS-CoV Apoptosis

Research Areas:

Infection Cancer

Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC₅₀=2 nM) and interferes with the assembly of the eIF4F initiation complex . Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC₉₀=37 nM) . Zotatifin induces cell apoptosis .

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Guanosine triphosphate disodium

11 Cited Publications

Cat. No.: HY-W010737

CAS No.: 56001-37-7

Synonyms: GTP disodium

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis

Guanosine triphosphate (GTP) disodium is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate disodium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate disodium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate disodium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate disodium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

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Guanosine triphosphate trisodium salt hydrate

11 Cited Publications

Cat. No.: HY-12695B

CAS No.: 207300-85-4

Purity: ≥95.0%

Synonyms: GTP trisodium salt hydrate

Category:

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis

Guanosine triphosphate (GTP) trisodium salt hydrate is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate trisodium salt hydrate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate trisodium salt hydrate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate trisodium salt hydrate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate trisodium salt hydrate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

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Lipoamide

10 Cited Publications

Cat. No.: HY-B1142

CAS No.: 940-69-2

Synonyms: (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide

Category:

Human Gut Microbiota Metabolites Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:

NO Synthase

Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

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Ferritin Heavy Chain Antibody (YA443)

10 Cited Publications

Cat. No.: HY-P80670

Synonyms: FTH; FTHL6; OK/SW-cl.84; PIG15; FTH1; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein

Host:

Rabbit

Application:

WB, ICC/IF

Reactivity:

Human, Mouse, Rat, Hamster

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