843

Dorsomorphin dihydrochloride

843 Publications Verification

Cat. No.: HY-13418

CAS No.: 1219168-18-9

Purity: 99.7%

Synonyms: BML-275 dihydrochloride; Compound C dihydrochloride

Target:

Organoid AMPK TGF-β Receptor Autophagy

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a K_i of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

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843

Dorsomorphin

843 Publications Verification

Cat. No.: HY-13418A

CAS No.: 866405-64-3

Purity: 99.10%

Synonyms: BML-275; Compound C

Target:

Organoid AMPK TGF-β Receptor Autophagy

Research Areas:

Inflammation/Immunology Cancer

Dorsomorphin (BML-275; Compound C) is a selective and ATP-competitive AMPK inhibitor (K_i=109 nM in the absence of AMP). Dorsomorphin selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) .

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97

LDN193189

97 Cited Publications

Cat. No.: HY-12071

CAS No.: 1062368-24-4

Purity: 99.41%

Synonyms: DM-3189

Target:

Organoid TGF-β Receptor

Research Areas:

Cancer

LDN193189 (DM-3189) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .

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97

LDN193189 Tetrahydrochloride

97 Cited Publications

Cat. No.: HY-12071A

CAS No.: 2310134-98-4

Purity: 99.79%

Synonyms: DM-3189 Tetrahydrochloride

Target:

Organoid TGF-β Receptor

Research Areas:

Cancer

LDN193189 (DM-3189) Tetrahydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .

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97

LDN193189 dihydrochloride

97 Cited Publications

Cat. No.: HY-12071B

CAS No.: 1435934-00-1

Purity: 99.75%

Synonyms: DM-3189 dihydrochloride

Target:

Organoid TGF-β Receptor

Research Areas:

Cancer

LDN193189 (DM-3189) dihydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .

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84

LDN193189 hydrochloride

84 Cited Publications

Cat. No.: HY-12071C

CAS No.: 1062368-62-0

Synonyms: DM-3189 hydrochloride

LDN193189 (DM-3189) hydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .

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24

BMP-2 Protein, Human/Mouse/Rat

24 Cited Publications

Cat. No.: HY-P7006

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: bmp2; SSFSC1; Prev. bmp2A; SSFSC; Bone Morphogenetic Protein 2A; bmp-2; bmp2 Protein; BDA2; Bone Morphogenetic Protein 2; bmp-2A

Species:

Rat Mouse Human

Source:

E. coli

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22

BMP-4 Protein, Human

22 Cited Publications

Cat. No.: HY-P7007

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: bmp4; MCOPS6; Prev. bmp2B; OFC11; Bone Morphogenetic Protein 2B; bmp-4; Bone Morphogenetic Protein 4 Preproprotein; ZYME; Alternative Protein bmp4; DVR4; bmp2B1; Bone Morphogenetic Protein 4; bmp-2B

Species:

Human

Source:

E. coli

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18

GW788388

18 Cited Publications

Cat. No.: HY-10326

CAS No.: 452342-67-5

Purity: 99.92%

Target:

TGF-β Receptor

Research Areas:

Cancer

GW788388 is a potent and selective inhibitor of ALK5 with IC₅₀ of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor.

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17

DMH-1

17 Cited Publications

Cat. No.: HY-12273

CAS No.: 1206711-16-1

Purity: 99.93%

Target:

TGF-β Receptor Organoid Microtubule/Tubulin

Research Areas:

Cardiovascular Disease Neurological Disease

DMH-1 is a selective BMP inhibitor. DMH-1 upregulates the expression of SOX1. DMH-1 increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons .

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10

BMP signaling agonist sb4

10 Cited Publications

Cat. No.: HY-124697

CAS No.: 100874-08-6

Purity: 99.98%

Target:

TGF-β Receptor

Research Areas:

Cancer

BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC₅₀ value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding,?Id1?and?Id3) canonical BMP signaling .

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