10

10 Publications Verification

Target:

Research Areas:

Alendronate acid is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate acid induces skeletal alterations in the chicken embryonic development model. Alendronate acid can be used for osteoporosis research .

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10

Alendronate sodium

10 Publications Verification

Cat. No.: HY-108685

CAS No.: 129318-43-0

Purity: ≥98.0%

Synonyms: Alendronic acid monosodium salt

Target:

NF-κB Interleukin Related

Research Areas:

Metabolic Disease

Alendronate sodium is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate sodium induces skeletal alterations in the chicken embryonic development model. Alendronate sodium can be used for osteoporosis research .

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6

Thonzonium bromide

6 Cited Publications

Cat. No.: HY-B1246

CAS No.: 553-08-2

Target:

Bacterial Proton Pump

Research Areas:

Infection

Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC₅₀=69 μM) .

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5

Denosumab

5 Cited Publications

Cat. No.: HY-P9958

CAS No.: 615258-40-7

Synonyms: AMG 162

Target:

NF-κB Caspase Apoptosis RANKL/RANK

Research Areas:

Metabolic Disease Cancer

Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

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5

Clodronic acid disodium salt

5 Cited Publications

Cat. No.: HY-B0657A

CAS No.: 22560-50-5

Synonyms: Clodronate disodium salt

Target:

Apoptosis

Research Areas:

Metabolic Disease Cancer

Clodronic acid (Clodronate) disodium salt is an orally active bisphosphonate. Clodronic acid disodium salt inhibits osteoclast-mediated bone resorption. Clodronic acid disodium salt reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid disodium salt is effective in the maintenance or improvement of bone mineral density. Clodronic acid disodium salt can be used for the research of multiple myeloma and postmenopausal osteoporosis .

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5

Eldecalcitol

5 Cited Publications

Cat. No.: HY-A0020

CAS No.: 104121-92-8

Synonyms: ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

Target:

VD/VDR Apoptosis

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1 .

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5

Denosumab (anti-TNFSF11)

5 Cited Publications

Cat. No.: HY-P9958A

CAS No.: 615258-40-7

Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

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5

Clodronic acid

5 Cited Publications

Cat. No.: HY-B0657

CAS No.: 10596-23-3

Synonyms: Clodronate

Target:

Apoptosis

Research Areas:

Metabolic Disease Cancer

Clodronic acid (Clodronate) is an orally active bisphosphonate. Clodronic acid inhibits osteoclast-mediated bone resorption. Clodronic acid reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid is effective in the maintenance or improvement of bone mineral density. Clodronic acid can be used for the research of multiple myeloma and postmenopausal osteoporosis .

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