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43 Results for "

brain microglia

" in MedChemExpress (MCE) Product Catalog:

Products (43)

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104

PLX5622

104 Publications Verification

Cat. No.: HY-114153

CAS No.: 1303420-67-8

Purity: 99.79%

Target:

c-Fms

Research Areas:

Neurological Disease Inflammation/Immunology

PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC₅₀=0.016 μM; K_i=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 is an ideal choose for microglia function research in healthy or diseased states. PLX5622 has been verified by MedChemExpress, which demonstrates desirable microglia depletion efficiency in mice. PLX5622 is predominantly administered via ad libitum diets with a dose of 1200 ppm .

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Sotuletinib

45 Cited Publications

Cat. No.: HY-12768

CAS No.: 953769-46-5

Purity: 99.83%

Synonyms: BLZ945

Target:

c-Fms

Research Areas:

Infection Neurological Disease Cancer

Sotuletinib (BLZ945) is a potent, selective, orally active and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC₅₀ of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs. Sotuletinib can be used for microglia depletion, and for tumor and CNS-related disease research .

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Sotuletinib hydrochloride

45 Cited Publications

Cat. No.: HY-12768A

CAS No.: 2222138-31-8

Purity: 99.43%

Synonyms: BLZ945 hydrochloride

Target:

c-Fms

Research Areas:

Cancer

Sotuletinib (BLZ945) hydrochloride is a potent, selective, orally active and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC₅₀ of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs. Sotuletinib hydrochloride can be used for microglia depletion, and for tumor and CNS-related disease research. .

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Stigmasterol

13 Cited Publications

Cat. No.: HY-N0131

CAS No.: 83-48-7

Category:

Endogenous metabolite

Target:

MMP Endogenous Metabolite

Stigmasterol is an orally acitve, immunomodulatory agent with anti-inflammatory and neuroprotective effect, as well as able to cross the blood-brain barrier. Stigmasterol activates AMPK, which in turn inhibits NF-κB and NLRP3 signaling pathways, reduces microglia-mediated neuroinflammation, and alleviates cognitive impairment and Alzheimer's disease. Stigmasterol regulates M1/M2 polarization of microglia through the TLR4/ NF-κB pathway, thereby reducing neuropathic pain. Stigmasterol can be used for neurodegenerative diseases, inflammatory diseases, and pain management, among others .

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JNJ-28583113

5 Cited Publications

Cat. No.: HY-149143

CAS No.: 2765255-93-2

Purity: 98.82%

Target:

TRP Channel

Research Areas:

Inflammation/Immunology

JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia .

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