7

TCID

7 Cited Publications

Cat. No.: HY-18638

CAS No.: 30675-13-9

Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione

Target:

Deubiquitinase

Research Areas:

Neurological Disease

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC₅₀ of 0.6 μM . TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons .

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Flavoxate hydrochloride

Cat. No.: HY-B0549A

CAS No.: 3717-88-2

Synonyms: Rec-7-0040; DW61

Target:

Calcium Channel Adenosine Receptor mAChR Dopamine Receptor Adrenergic Receptor

Research Areas:

Cardiovascular Disease Infection Neurological Disease Cancer

Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

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Butamirate

Cat. No.: HY-118545

CAS No.: 18109-80-3

Target:

STAT

Research Areas:

Inflammation/Immunology Cancer

Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma .

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Butamirate citrate

Cat. No.: HY-118545A

CAS No.: 18109-81-4

Purity: 99.88%

Target:

STAT

Research Areas:

Inflammation/Immunology Cancer

Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma .

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Butamirate citrate (Standard)

Cat. No.: HY-118545AR

CAS No.: 18109-81-4

Target:

Reference Standards STAT

Research Areas:

Inflammation/Immunology Cancer

Butamirate citrate (Standard) is the analytical standard of Butamirate citrate (HY-118545A). This product is intended for research and analytical applications. Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma .

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Flavoxate

Cat. No.: HY-B0549

CAS No.: 15301-69-6

Synonyms: Rec-7-0040 free base; DW61 free base

Target:

mAChR Calcium Channel Adrenergic Receptor Adenosine Receptor Dopamine Receptor

Research Areas:

Neurological Disease

Flavoxate (Rec-7-0040 free base; DW61 free base) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate can be used in research on overactive bladder and related voiding dysfunctions .

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Flavoxate hydrochloride (Standard)

Cat. No.: HY-B0549AR

CAS No.: 3717-88-2

Synonyms: Rec-7-0040 (Standard); DW61 (Standard)

Target:

Reference Standards mAChR Calcium Channel Adrenergic Receptor Adenosine Receptor Dopamine Receptor

Research Areas:

Neurological Disease

Flavoxate (hydrochloride) (Standard) is the analytical standard of Flavoxate (hydrochloride). This product is intended for research and analytical applications. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

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Inaperisone

Cat. No.: HY-128469

CAS No.: 99323-21-4

Purity: ≥99.0%

Target:

GABA Receptor

Research Areas:

Neurological Disease

Inaperisone is a centrally acting muscle relaxant. Inaperisone can inhibit the micturition reflex by acting indirectly on GABAB receptors in the brainstem .

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LPLRF-NH2

Cat. No.: HY-P3593

CAS No.: 88280-21-1

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease Neurological Disease

LPLRF-NH2 is a member of RFamide peptide with anorexigenic effect. LPLRF-NH2 increases arterial blood pressure and modulates the electrical activity of brainstem neurons .

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LY134046

Cat. No.: HY-136625

CAS No.: 71274-97-0

Target:

N-myristoyltransferase

Research Areas:

Cardiovascular Disease

LY134046 is an inhibitor of norepinephrine N-methyltransferase (NMT) with cardiovascular activity. LY134046 causes sustained reductions in mean arterial blood pressure and heart rate, but no significant reductions in norepinephrine concentrations in the rat brain. LY134046 does not interact with adrenergic or cholinergic receptors, and its hypotensive and bradycardic effects do not require neurogenic tension. LY134046 (40 mg/kg/day) causes sustained and significant inhibition of hypothalamic and brainstem NMT activity, resulting in central norepinephrine depletion.

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Flavoxate-d5

Cat. No.: HY-B0549S

CAS No.: 2748541-85-5

Flavoxate-d₅ is deuterium labeled Flavoxate. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

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Flavoxate-d4 hydrochloride

Cat. No.: HY-B0549AS

CAS No.: 1189678-43-0

Flavoxate-d₄ hydrochloride (Rec-7-0040-d₄) is the deuterium labeled Flavoxate hydrochloride. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

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Hexahydrosiladifenidol

Cat. No.: HY-189031

CAS No.: 98299-40-2

Target:

mAChR

Research Areas:

Others

Hexahydrosiladifenidol is a muscarinic receptor antagonist. Hexahydrosiladifenidol blocks sympathetic ganglion M₁ and brainstem M₂ muscarinic receptors .

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