11

Cromolyn disodium

11 Publications Verification

Cat. No.: HY-B0320A

CAS No.: 15826-37-6

Synonyms: Cromoglycate disodium; Cromoglicic acid disodium; FPL-670

Target:

GSK-3 NF-κB Amyloid-β

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

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11

Cromolyn

11 Publications Verification

Cat. No.: HY-B1619

CAS No.: 16110-51-3

Synonyms: Cromoglycate; Cromoglicic acid; FPL-670 free acid

Target:

GSK-3 NF-κB Amyloid-β

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

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6

Methacholine chloride

6 Cited Publications

Cat. No.: HY-A0083

CAS No.: 62-51-1

Synonyms: Acetyl-β-methylcholine chloride

Target:

mAChR

Research Areas:

Others

Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .

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4

Thiorphan

4 Cited Publications

Cat. No.: HY-W013375

CAS No.: 76721-89-6

Target:

Neprilysin

Research Areas:

Neurological Disease

Thiorphan is a selective neprilysin (NEP) inhibitor with an IC₅₀ of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .

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2

Tiotropium Bromide

2 Cited Publications

Cat. No.: HY-17360

CAS No.: 136310-93-5

Synonyms: BA679 BR

Target:

mAChR

Research Areas:

Inflammation/Immunology

Tiotropium bromide (BA-679 BR) is a long-acting anticholinergic bronchodilator. Tiotropium bromide blocks the action of acetylcholine at muscarinic M1, M2, and M3 receptors, prevents bronchoconstriction, and dilates bronchial airways. Tiotropium bromide is applicable to research related to chronic obstructive pulmonary disease and asthma .

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2

Tiotropium bromide monohydrate

2 Cited Publications

Cat. No.: HY-B0460

CAS No.: 411207-31-3

Synonyms: BA-679 BR monohydrate

Target:

mAChR

Research Areas:

Inflammation/Immunology

Tiotropium bromide monohydrate (BA-679 BR monohydrate) is a long-acting anticholinergic bronchodilator. Tiotropium bromide monohydrate blocks the action of acetylcholine at muscarinic M1, M2, and M3 receptors, prevents bronchoconstriction, and dilates bronchial airways. Tiotropium bromide monohydrate is applicable to research related to chronic obstructive pulmonary disease and asthma .

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