29 Results for "

cAMP response element

" in MedChemExpress (MCE) Product Catalog:
Products (29)

29 Results for "cAMP response element" in MCE Product Catalog:

4
PU139
PU139
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4 Cited Publications
Cat. No.: HY-124696
CAS No.: 158093-65-3
Purity:  99.14%
Target:  

Histone Acetyltransferase

Research Areas:  

Cancer

PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively .
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Crebinostat
Crebinostat
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1 Cited Publications
Cat. No.: HY-116818
CAS No.: 1092061-61-4
Purity:  99.79%
Target:  

HDAC

Research Areas:  

Neurological Disease

Crebinostat is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.7 nM, 1.0 nM, 2.0 nM and 9.3 nM for HDAC1, HDAC2, HDAC3 and HDAC6, respectively. Crebinostat potently induces acetylation of both histone H3 and histone H4 as well as enhances the expression of the cAMP response element-binding protein (CREB) target gene Egr1. Crebinostat increases the density of synapsin-1 punctae along dendrites in cultured neurons. Crebinostat can modulate chromatin-mediated neuroplasticity and exhibits enhanced memory in mice .
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Metadoxine
Metadoxine
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Cat. No.: HY-B1898
CAS No.: 74536-44-0
Target:  

PKA

Research Areas:  

Metabolic Disease

Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.
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2-Ethoxybenzamide
2-Ethoxybenzamide
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Cat. No.: HY-B1428
CAS No.: 938-73-8
Synonyms: Ethenzamide
Target:  

Tyrosinase Reactive Oxygen Species (ROS) PERK

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

2-Ethoxybenzamide (Ethenzamide) is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects. 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation. 2-Ethoxybenzamide can be used in the research of hypopigmentation and inflammation-related diseases .
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CREBtide
CREBtide
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Cat. No.: HY-P1595
CAS No.: 149155-45-3
Target:  

PKA PKC

Research Areas:  

Metabolic Disease

CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA and PKC substrate.
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653-47 hydrochloride
653-47 hydrochloride
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Cat. No.: HY-134598A
CAS No.: 1224567-46-7
Purity:  99.42%
Target:  

Epigenetic Reader Domain

Research Areas:  

Cancer

653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM .
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PDE7-IN-4
PDE7-IN-4
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Cat. No.: HY-114727
CAS No.: 18741-24-7
Purity:  98.55%
Target:  

Phosphodiesterase (PDE)

Research Areas:  

Inflammation/Immunology

PDE7-IN-4 is a phosphodiesterase 7 (PDE7) inhibitor with activity that increases intracellular cyclic adenosine monophosphate (cAMP) levels. PDE7-IN-4 shows potential inhibitory effects in neurotransmission and anti-inflammatory applications. PDE7-IN-4 exerts its biological activity by acting on the cAMP/cAMP response element binding protein (CREB) pathway. The development of PDE7-IN-4 aims to improve its pharmacokinetic characteristics to more effectively target neurodegenerative diseases and other inflammation-related diseases .
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PPZ2
PPZ2
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Cat. No.: HY-111527
CAS No.: 896203-18-2
Purity:  99.92%
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects .
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Kiss2 peptide acetate
Kiss2 peptide acetate
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Cat. No.: HY-P10256A
Target:  

Kisspeptin Receptor PKA PKC

Research Areas:  

Endocrinology

Kiss2 peptide acetate is the acetate form of Kiss2 pepride (HY-P10256). Kiss2 peptide acetate is a positive regulator of reproduction. Kiss2 peptide acetate binds with its cognate receptor Kiss2R (GPR54) in COS-7 cells, activates PKA and PKC signaling pathways through Gas and Gaq proteins, and thus enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc) .
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TrkB activator-1
TrkB activator-1
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Cat. No.: HY-175483S
CAS No.: 3087336-56-6
TrkB activator-1 is a specific, orally active and brain-penetrant tropomyosin receptor kinase B (TrkB) activator. TrkB activator-1 shows potent antidepressant effects through activation of the activates the BDNF (brainderived neurotrophic factor)-Tropomyosin-related kinase B (TrkB)-CREB (cAMP response element binding protein) signaling aixs. TrkB activator-1 increaes neuroplasticity. TrkB activator-1 can be used for the research of neurological disease, such as depression .
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SIK2-IN-4
SIK2-IN-4
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Cat. No.: HY-171591
CAS No.: 2810810-00-3
Target:  

Salt-inducible Kinase (SIK) Interleukin Related TNF Receptor

Research Areas:  

Infection

SIK2-IN-4 (Compound 4) is a highly selective SIK1/2 inhibitor (IC50s 0.143 and 0.076 μM, respectively). SIK2-IN-4 reduces the phosphorylation of transcription coactivator 3 (CRTC3) by targeting SIK1/2, thereby regulating cAMP response element binding protein (CREB)-dependent transcriptional activity. SIK2-IN-4 inhibits the production of pro-inflammatory cytokines such as TNF (IC50: 0.11 µM), IL-12/23 p40 (IC50: 0.25 µM), and IL-23 (IC50: 0.47 µM), while inducing the expression of the anti-inflammatory cytokine IL-10. SIK2-IN-4 can be used to study intestinal inflammation and other chronic inflammatory diseases .
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DS1
DS1
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Cat. No.: HY-136942
CAS No.: 372497-52-4
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

DS1 is a potent GABAA agonist. DS1 increases the activity of serum response element (SRE) and cAMP response element (CRE) promoters. DS1 induces luteinizing hormone beta (LHbeta) and follicle-stimulating hormone beta (FSHbeta) promoter activity .
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Kiss2 peptide
Kiss2 peptide
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Cat. No.: HY-P10256
CAS No.: 1111070-93-9
Target:  

Kisspeptin Receptor PKA PKC

Research Areas:  

Endocrinology

Kiss2 peptide is a positive regulator of reproduction. Kiss2 peptide binds with its cognate receptor Kiss2R (GPR54) in COS-7 cells, activates PKA and PKC signaling pathways through Gas and Gaq proteins, and thus enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc) .
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CREBtide TFA
CREBtide TFA
0 Images
Cat. No.: HY-P1595A
Target:  

PKA PKC

Research Areas:  

Metabolic Disease

CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a PKA and PKC substrate .
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653-47
653-47
0 Images
Cat. No.: HY-134598
CAS No.: 1224678-75-4
Target:  

Epigenetic Reader Domain

Research Areas:  

Cancer

653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM .
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Prolylserine
Prolylserine
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Cat. No.: HY-P4497
CAS No.: 71835-80-8
Target:  

ERK

Research Areas:  

Cancer

Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB) .
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2-Ethoxybenzamide (Standard)
2-Ethoxybenzamide (Standard)
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Cat. No.: HY-B1428R
CAS No.: 938-73-8
Synonyms: Ethenzamide (Standard)
Target:  

Reference Standards Tyrosinase Reactive Oxygen Species (ROS) PERK

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

2-Ethoxybenzamide (Standard) is the analytical standard of 2-Ethoxybenzamide (HY-B1428). 2-Ethoxybenzamide (Ethenzamide) is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects. 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation. 2-Ethoxybenzamide can be used in the research of hypopigmentation and inflammation-related diseases .
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Dodoviscin A
Dodoviscin A
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Cat. No.: HY-N3773
CAS No.: 1372527-25-7
Category:  

Sapindaceae Extract Flavonoids Flavones 500 - Internal Server Error | MedChemExpress

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