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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
cEt gapmer
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "cEt gapmer" in MCE Product Catalog:
9
Research Areas:
5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity .
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5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds .
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5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice .
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5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .
Cat. No.: HY-148688
Purity: 96.25%
Target:
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ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5’-GmCATTmCTAATAGmCAGmC-3’ .
Cat. No.: HY-173193
CAS No.: 945628-51-3
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S-cEt-U phosphoramidite is a modified phosphoramidite monomer that can be used for the oligonucleotide synthesis .
Cat. No.: HY-P3392
CAS No.: 2305355-56-8
Synonyms: ION373
Target:
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Zilganersen (ION373) is a gapmer antisense oligonucleotide targeting glial fibrillary acidic protein (GFAP). Zilganersen reduces excess glial fibrillary acidic protein produced by disease-causing variants in the GFAP gene and inhibits synthesis of GFAP. Zilganersen can be used for the research of Alexander disease .
Cat. No.: HY-P3392A
CAS No.: 2305355-64-8
Synonyms: ION373 sodium
Target:
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Zilganersen (ION373) sodium is a gapmer antisense oligonucleotide targeting glial fibrillary acidic protein (GFAP). Zilganersen sodium reduces excess glial fibrillary acidic protein produced by disease-causing variants in the GFAP gene and inhibits synthesis of GFAP. Zilganersen sodium can be used for the research of Alexander disease .
0 Images
ION-626112 (sodium)
Cat. No.: HY-159693A
Synonyms: ION-626112 sodium
Cat. No.: HY-W190913
CAS No.: 2226472-28-0
Research Areas:
DBCO-PEG4-Val-Cit-PAB-PNP is a linker. DBCO-PEG4-Val-Cit-PAB-PNP conjugates anti-SYT2 monoclonal antibody with MALAT1 gapmer antisense oligonucleotides without inhibiting ASO activity or impairing the binding efficiency of the antibody to SYT2 antigen .
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ION-626112
Cat. No.: HY-159693
CAS No.: 2091995-55-8
Synonyms: ION-626112
Cat. No.: HY-177629
CAS No.: 2756001-75-7
Synonyms: PRAX-222
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Elsunersen (PRAX‑222) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen reduces the protein level of the voltage-gated sodium channel NaV1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability . Elsunersen combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen can be used in research related to epileptic encephalopathy .
Cat. No.: HY-158821A
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ISTH0036 sodium is a phosphorothioate LNA-modified antisense oligonucleotide gapmer that selectively targets and downregulates TGF-β2 mRNA. ISTH0036 sodium suppresses TGF-β2 expression, reduces choroidal neovascularization and vascular leakage, inhibits fibrosis, blocks epithelial-to-mesenchymal transition, and inhibits angiogenesis while promoting bleb survival. ISTH0036 sodium exhibits long-lasting, dose-dependent ocular tissue distribution and target engagement in rabbit and non-human primate eyes. ISTH0036 sodium can be used for the study of various ocular disorders, such as glaucoma and neovascular retinal diseases .
Cat. No.: HY-177629A
Synonyms: PRAX-222 sodium
Target:
Research Areas:
Elsunersen sodium (PRAX‑222 sodium) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen sodium reduces the protein level of the voltage-gated sodium channel NaV1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability . Elsunersen sodium combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen sodium can be used in research related to epileptic encephalopathy .
Cat. No.: HY-158821
CAS No.: 2179222-27-4
Target:
Research Areas:
ISTH0036 is a phosphorothioate LNA-modified antisense oligonucleotide gapmer that selectively targets and downregulates TGF-β2 mRNA. ISTH0036 suppresses TGF-β2 expression, reduces choroidal neovascularization and vascular leakage, inhibits fibrosis, blocks epithelial-to-mesenchymal transition, and inhibits angiogenesis while promoting bleb survival. ISTH0036 exhibits long-lasting, dose-dependent ocular tissue distribution and target engagement in rabbit and non-human primate eyes. ISTH0036 can be used for the study of various ocular disorders, such as glaucoma and neovascular retinal diseases .
Cat. No.: HY-205155
CAS No.: 945628-57-9
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5'-ODMT cEt N-Bz C Phosphoramidite (Amidite) is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-180479
CAS No.: 945628-63-7
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Nucleoside-analog-3 (compound 59) is a S-cEt guanosine intermediate .
Cat. No.: HY-148688H
Target:
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ASO 556089 (with PS modification) sodium is the PS-modified version of ASO 556089 (HY-148688). ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5’-GmCATTmCTAATAGmCAGmC-3’ .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
