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68 Results for "

caged

" in MedChemExpress (MCE) Product Catalog:

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UNC6852

5 Cited Publications

Cat. No.: HY-130708

CAS No.: 2688842-08-0

Purity: 99.60%

Target:

PROTACs Histone Methyltransferase

Research Areas:

Cancer

UNC6852 is a PRC2 PROTAC degrader, with a DC₅₀ value of 0.79 μM for EED (HeLa), 0.3 μM for EZH2 (HeLa), and 0.59 μM for SUZ12 (DLBCL). UNC6852 binds to the WD40 aromatic cage of EED and CRL2-VHL, inducing proteasomal degradation of EED, EZH2 and SUZ12. UNC6852 reduces the level of H₃K₂₇me₃ and exerts antiproliferative effects in cancer cells. UNC6852 can be used in studies related to diffuse large B-cell lymphoma, triple-negative breast cancer and prostate cancer .

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DPI-4452

1 Cited Publications

Cat. No.: HY-P10761

CAS No.: 2941391-49-5

Target:

Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase

Research Areas:

Cancer

DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC₅₀ for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

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Asfotase alfa

Cat. No.: HY-108786

CAS No.: 1174277-80-5

Purity: 97.88%

Synonyms: ENB-0040

Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 ^/ knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) .

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