2286 Results for "

calcium dependency

" in MedChemExpress (MCE) Product Catalog:

Products (2286)

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202

Doxycycline monohydrate

202 Publications Verification

Cat. No.: HY-W008923

CAS No.: 17086-28-1

Target:

MMP Parasite Bacterial Antibiotic Apoptosis Akt PI3K

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline monohydrate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline monohydrate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline monohydrate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline monohydrate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline monohydrate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline monohydrate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .

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142

Ionomycin calcium

142 Cited Publications

Cat. No.: HY-13434A

CAS No.: 56092-82-1

Purity: 98.02%

Synonyms: SQ23377 calcium

Category:

Infection Microorganisms Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics

Target:

Calcium Channel PKC Bacterial Apoptosis Antibiotic

Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

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142

Ionomycin

142 Cited Publications

Cat. No.: HY-13434

CAS No.: 56092-81-0

Purity: 99.27%

Synonyms: SQ23377

Category:

Infection Microorganisms Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics

Target:

Calcium Channel PKC Bacterial Apoptosis Antibiotic

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

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122

Yoda 1

122 Cited Publications

Cat. No.: HY-18723

CAS No.: 448947-81-7

Target:

Piezo Channel Akt ERK Potassium Channel

Research Areas:

Cardiovascular Disease

Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca ²⁺ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation .

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Verapamil

98 Cited Publications

Cat. No.: HY-14275

CAS No.: 52-53-9

Purity: 98.96%

Synonyms: (±)-Verapamil; CP-16533-1

Target:

Calcium Channel P-glycoprotein Cytochrome P450

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

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Verapamil hydrochloride

98 Cited Publications

Cat. No.: HY-A0064

CAS No.: 152-11-4

Synonyms: (±)-Verapamil hydrochloride; CP-16533-1 hydrochloride

Target:

Calcium Channel P-glycoprotein Cytochrome P450

Research Areas:

Cardiovascular Disease Cancer

Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

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L-Ascorbic acid calcium dihydrate

85 Cited Publications

Cat. No.: HY-B0166C

CAS No.: 5743-28-2

Synonyms: L-Ascorbate calcium dihydrate; Vitamin C calcium dihydrate

Target:

Endogenous Metabolite Calcium Channel Reactive Oxygen Species (ROS) Apoptosis

L-Ascorbic acid calcium dihydrate (L-Ascorbate calcium dihydrate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid calcium dihydrate inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid calcium dihydrate is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid calcium dihydrate exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

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