122

122 Publications Verification

Target:

Research Areas:

Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca ²⁺ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation .

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32

TRAM-34

32 Cited Publications

Cat. No.: HY-13519

CAS No.: 289905-88-0

Purity: 99.73%

Target:

Potassium Channel

Research Areas:

Neurological Disease

TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K ⁺ channel (IKCa1) (K_d=20 nM).

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12

CaCCinh-A01

12 Cited Publications

Cat. No.: HY-100611

CAS No.: 407587-33-1

Purity: 99.35%

Target:

Chloride Channel

Research Areas:

Inflammation/Immunology Cancer

CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC₅₀s of 2.1 and 10 μM, respectively.

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8

Hydrochlorothiazide

8 Cited Publications

Cat. No.: HY-B0252

CAS No.: 58-93-5

Synonyms: HCTZ

Target:

TGF-beta/Smad Potassium Channel

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

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8

(E/Z)-BML264

8 Cited Publications

Cat. No.: HY-118628

CAS No.: 110683-10-8

Purity: 99.63%

Synonyms: N-(p-Amylcinnamoyl) anthranilic acid; ACA

Target:

Phospholipase TRP Channel

Research Areas:

Cardiovascular Disease

(E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A₂ (PLA₂) inhibitor and TRP channel blocker . (E/Z)-BML264 is a SLC13A3 inhibitor. (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia .

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6

Niflumic acid

6 Cited Publications

Cat. No.: HY-B0493

CAS No.: 4394-00-7

Target:

Chloride Channel COX

Research Areas:

Inflammation/Immunology Cancer

Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC₅₀ value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis .

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4

E 64c

4 Cited Publications

Cat. No.: HY-100227

CAS No.: 76684-89-4

Target:

Cathepsin SARS-CoV

Research Areas:

Metabolic Disease

E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV.

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3

T16Ainh-A01

3 Cited Publications

Cat. No.: HY-100612

CAS No.: 552309-42-9

Purity: ≥99.0%

Target:

Chloride Channel

Research Areas:

Others

T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC₅₀ value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC) .

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2

Rimtuzalcap

2 Cited Publications

Cat. No.: HY-109160

CAS No.: 2167246-24-2

Purity: 99.27%

Synonyms: CAD-1883

Target:

Potassium Channel

Research Areas:

Neurological Disease

Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA) .

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