110

KN-93

110 Publications Verification

Cat. No.: HY-15465

CAS No.: 139298-40-1

Purity: 99.42%

Target:

CaMK Autophagy

Research Areas:

Cancer

KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a K_i of 370 nM.

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110

KN-93 phosphate

110 Publications Verification

Cat. No.: HY-15465B

CAS No.: 1913269-12-1

Purity: 99.67%

Target:

CaMK Autophagy

Research Areas:

Cancer

KN-93 phosphate is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM .

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110

KN-93 hydrochloride

110 Publications Verification

Cat. No.: HY-15465A

CAS No.: 1956426-56-4

Purity: 99.64%

Target:

CaMK Autophagy

Research Areas:

Cancer

KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a K_i of 370 nM.

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39

STO-609

39 Cited Publications

Cat. No.: HY-19805

CAS No.: 52029-86-4

Target:

CaMK AMPK Autophagy

Research Areas:

Metabolic Disease

STO-609 is a selective and cell-permeable inhibitor of the Ca ²⁺/calmodulin-dependent protein kinase kinase (CaM-KK), with K_i values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC₅₀ ~0.02 g/ml.

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27

K-252a

27 Cited Publications

Cat. No.: HY-N6732

CAS No.: 99533-80-9

Synonyms: SF2370; Antibiotic K 252a; Antibiotic SF 2370

Category:

Alkaloids Microorganisms Disease Research Fields Inflammation/Immunology Indole Alkaloids

Target:

Autophagy PKA PKC Trk Receptor CaMK

K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

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14

KN-62

14 Cited Publications

Cat. No.: HY-13290

CAS No.: 127191-97-3

Purity: 99.45%

Target:

CaMK P2X Receptor

Research Areas:

Metabolic Disease Cancer

KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a K_i of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X₇ receptors in HEK293 cells, with an IC₅₀ value of approximately 15 nM.

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10

W-7 hydrochloride

10 Cited Publications

Cat. No.: HY-100912

CAS No.: 61714-27-0

Purity: 99.96%

Target:

Phosphodiesterase (PDE) Myosin Apoptosis Calmodulin Potassium Channel

Research Areas:

Cancer

W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca ²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias .

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10

W-7

10 Cited Publications

Cat. No.: HY-130368

CAS No.: 65595-90-6

Target:

Calmodulin Potassium Channel Phosphodiesterase (PDE) Myosin Apoptosis

Research Areas:

Cardiovascular Disease

W-7 is a selective calmodulin antagonist. W-7 inhibits the Ca ²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 μM, respectively. W-7 induces apoptosis and has antitumor and vascular relaxing activity. W-7 is a blocker of Kv4.3 and can be used for research of arrhythmias .

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9

DCP-LA

9 Cited Publications

Cat. No.: HY-108599

CAS No.: 28399-31-7

Purity: ≥98.0%

Synonyms: FR236924

Target:

PKC CaMK Phosphatase Apoptosis

Research Areas:

Neurological Disease

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( ²⁺)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis .

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2

Myelin basic protein (4-14)

2 Cited Publications

Cat. No.: HY-P1821

CAS No.: 126768-94-3

Synonyms: MHP4-14

Target:

PKC

Research Areas:

Neurological Disease Inflammation/Immunology

Myelin basic protein 4-14 (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

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2

Myelin basic protein (4-14) TFA

2 Cited Publications

Cat. No.: HY-P1821A

Synonyms: MHP4-14 TFA

Target:

PKC

Research Areas:

Neurological Disease

Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

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2

CaMKII alpha Antibody (YA569)

2 Cited Publications

Cat. No.: HY-P80445

Synonyms: Alpha CaMKII; Calcium calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II alpha B subunit; Calcium/calmodulin dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; Calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase II-alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type IIA; CaM kinase II alpha chain; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaMK II alpha subunit; CaMK-II subunit alpha; Camk2a; CAMKA; CaMKII; CaMKIINalpha; EC2.7.11.17; KCC2A_HUMAN; KIAA0968; MGC123320; MGC139375; MGC155201; mKIAA0968; PK2CDD; PKCCD; R74975; zgc:112538; zgc:123320;

Host:

Rabbit

Application:

WB, IP, FC, IHC-P

Reactivity:

Human, Mouse, Rat

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