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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
313 Results for "
casein kinase
" in MedChemExpress (MCE) Product Catalog:
Products (313)
313 Results for "casein kinase" in MCE Product Catalog:
1253
1253 Publications Verification
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LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC50 values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research .
1253
1253 Publications Verification
LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively . LY294002 also inhibits CK2 with an IC50 of 98 nM . LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. LY294002 is an apoptosis activator .
204
204 Cited Publications
Cat. No.: HY-15979
CAS No.: 127243-85-0
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H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases.
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Lenalidomide (CC-5013) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide promotes IL-2 release and effector functions of CD8 + T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide can be used in research related to hematological malignancies, acute liver failure and acute kidney injury .
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Lenalidomide hemihydrate (CC-5013 hemihydrate) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide hemihydrate induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide hemihydrate promotes IL-2 release and effector functions of CD8 + T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide hemihydrate can be used in research related to hematological malignancies, acute liver failure and acute kidney injury .
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Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'.
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Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'.
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Endogenous metabolite Polygonaceae Extract Quinones Human Gut Microbiota Metabolites Plant Anthraquinones Phenols Polyphenols Rheum palmatum L. Extract Microorganism Disease Research Fields Cancer
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37
37 Cited Publications
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IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ .
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23 Cited Publications
Cat. No.: HY-B0183A
CAS No.: 314041-08-2
Category:
Plant Ziziphus jujuba Mill. Extract Phenols Polyphenols Disease Research Fields Rhamnaceae Extract Cancer
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15 Cited Publications
Synonyms: NSC 231634; casein kinase II Inhibitor I
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TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC50 of 0.15 μM for rat liver CK2.
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14 Cited Publications
Synonyms: casein kinase I Inhibitor
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D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1) with an IC50 value of 0.3 μM in vitro.
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12 Cited Publications
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TAK-715 is an orally active and potent p38 MAPK inhibitor with IC50s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model .
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9 Cited Publications
Synonyms: CK2 Inhibitor; casein kinase II Inhibitor
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DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.
9
5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis .
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8 Cited Publications
PF-670462 dihydrochloride is a selective CK1δ and CK1δε inhibitor (Ki of 10 nM and 50 nM, respectively). PF-670462 dihydrochloride is also a ZDHHC8-specific inhibitor (Kd 15.9 μM). PF-670462 dihydrochloride inhibits CK1-mediated LRRK2 phosphorylation. PF-670462 dihydrochloride blocks PER phosphorylation and CK1δ/ε-dependent TGF-β signaling. PF-670462 dihydrochloride reduces GPX4 palmitoylation, sensitizing tumor cells to Ferroptosis inducers. PF-670462 dihydrochloride can be used for research on Parkinson's disease, NRAS-mutant melanoma, pulmonary fibrosis, chronic lymphocytic leukemia, diabetic nephropathy, and melanoma .
8
8 Cited Publications
Cat. No.: HY-15490A
CAS No.: 950980-98-0
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
PF-670462 is a selective CK1δ and CK1δε inhibitor (Ki of 10 nM and 50 nM, respectively). PF-670462 is also a ZDHHC8-specific inhibitor (Kd 15.9 μM). PF-670462 inhibits CK1-mediated LRRK2 phosphorylation. PF-670462 blocks PER phosphorylation and CK1δ/ε-dependent TGF-β signaling. PF-670462 reduces GPX4 palmitoylation, sensitizing tumor cells to Ferroptosis inducers. PF-670462 can be used for research on Parkinson's disease, NRAS-mutant melanoma, pulmonary fibrosis, chronic lymphocytic leukemia, diabetic nephropathy, and melanoma .
5
5 Cited Publications
Synonyms: TGR-1202; RP5264
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Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
