881

Z-VAD-FMK

881 Publications Verification

Cat. No.: HY-16658B

CAS No.: 161401-82-7

Synonyms: Z-VAD(OH)-FMK

Target:

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

Research Areas:

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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264

Nigericin sodium salt

264 Cited Publications

Cat. No.: HY-100381

CAS No.: 28643-80-3

Purity: 99.37%

Category:

Infection Microorganisms Antibiotics Disease Research Disease Research Fields Other Antibiotics Cancer

Target:

Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin

Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

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264

Nigericin

264 Cited Publications

Cat. No.: HY-127019

CAS No.: 28380-24-7

Purity: 99.43%

Target:

Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin

Research Areas:

Infection Cancer

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC .

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213

Z-VAD(OMe)-FMK

213 Cited Publications

Cat. No.: HY-16658

CAS No.: 187389-52-2

Synonyms: Z-Val-Ala-Asp(OMe)-FMK

Target:

Caspase

Research Areas:

Cancer

Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor . Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .

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187

Belnacasan

187 Cited Publications

Cat. No.: HY-13205

CAS No.: 273404-37-8

Purity: 99.99%

Synonyms: VX-765

Target:

Caspase

Research Areas:

Inflammation/Immunology

Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with K_is of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC₅₀ of ~0.7 μM .

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154

Necrosulfonamide

154 Cited Publications

Cat. No.: HY-100573

CAS No.: 1360614-48-7

Purity: 99.47%

Target:

Mixed Lineage Kinase Necroptosis Pyroptosis Caspase NOD-like Receptor (NLR) Keap1-Nrf2 TNF Receptor Interleukin Related NO Synthase Heme Oxygenase (HO)

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology

Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways .

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143

Z-DEVD-FMK

143 Cited Publications

Cat. No.: HY-12466

CAS No.: 210344-95-9

Purity: ≥98.0%

Target:

Caspase

Research Areas:

Cancer

Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC₅₀ of 18 μM .

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123

Q-VD-OPh

123 Cited Publications

Cat. No.: HY-12305

CAS No.: 1135695-98-5

Purity: 99.92%

Synonyms: QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone

Target:

Caspase HIV

Research Areas:

Infection Cancer

Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC₅₀ of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.

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114

Tauroursodeoxycholate sodium

114 Cited Publications

Cat. No.: HY-19696A

CAS No.: 35807-85-3

Synonyms: Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

ERK Caspase Apoptosis Endogenous Metabolite

Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

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114

Tauroursodeoxycholate

114 Cited Publications

Cat. No.: HY-19696

CAS No.: 14605-22-2

Synonyms: Tauroursodeoxycholic acid; TUDCA; UR 906

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

ERK Caspase Endogenous Metabolite Apoptosis

Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an orally active endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK .

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114

Tauroursodeoxycholate dihydrate

114 Cited Publications

Cat. No.: HY-19696B

CAS No.: 117609-50-4

Synonyms: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt

Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .

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73

Z-IETD-FMK

73 Cited Publications

Cat. No.: HY-101297

CAS No.: 210344-98-2

Purity: ≥98.0%

Synonyms: Z-IE(OMe)TD(OMe)-FMK

Target:

Caspase

Research Areas:

Cancer

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .

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63

Emricasan

63 Cited Publications

Cat. No.: HY-10396

CAS No.: 254750-02-2

Purity: 99.81%

Synonyms: PF 03491390; IDN-6556

Target:

Caspase Flavivirus

Research Areas:

Infection Neurological Disease Cancer

Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors .

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61

Rimiducid

61 Cited Publications

Cat. No.: HY-16046

CAS No.: 195514-63-7

Synonyms: AP1903

Target:

FKBP Apoptosis

Research Areas:

Cancer

Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.

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