159 Results for "

catalytically active

" in MedChemExpress (MCE) Product Catalog:
Products (159)

159 Results for "catalytically active" in MCE Product Catalog:

17
PHA-665752
PHA-665752
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17 Publications Verification
Cat. No.: HY-11107
CAS No.: 477575-56-7
Purity:  99.86%
Target:  

c-Met/HGFR Autophagy Apoptosis

Research Areas:  

Cancer

PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase (Ki=4 nM; IC50=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity .
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4
BLU0588
BLU0588
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4 Cited Publications
Cat. No.: HY-153967
CAS No.: 2810747-78-3
Purity:  95.92%
Target:  

PKA

Research Areas:  

Cancer

BLU0588 is an orally active, potent and selective PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor, with an IC50 of 1 nM and dissociation constant (Kd) of 4 nM. BLU0588 can be used for fibrolamellar carcinoma (FLC) research .
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3
RG3039
RG3039
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3 Cited Publications
Cat. No.: HY-102020
CAS No.: 1005504-62-0
Purity:  99.62%
Synonyms: PF-06687859
Target:  

DNA/RNA Synthesis Ligands for Target Protein for PROTAC

Research Areas:  

Neurological Disease

RG3039 (PF-06687859) is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC50 of 4.2 nM against hDcpS. RG3039 inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 extends survival and improves function in spinal muscular atrophy mice. RG3039 is applicable to research related to spinal muscular atrophy .
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2
Elsubrutinib
Elsubrutinib
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2 Cited Publications
Cat. No.: HY-109143
CAS No.: 1643570-24-4
Purity:  ≥98.0%
Synonyms: ABBV-105
Target:  

Btk

Research Areas:  

Inflammation/Immunology

Elsubrutinib (ABBV-105) is an orally active, potent, selective and irreversible Bruton's tyrosine kinase (BTK) inhibitor. The IC50 of Elsubrutinib for BTK catalytic domain is 0.18 μM. Elsubrutinib can be used for the research of inflammatory disease .
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2
TAK-418
TAK-418
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2 Cited Publications
Cat. No.: HY-138830
CAS No.: 1818252-53-7
Purity:  99.81%
Target:  

Histone Demethylase

Research Areas:  

Neurological Disease

TAK-418 is an orally active, blood-brain barrier-penetrant LSD1 inhibitor with a human IC50 of 2.9 nM. TAK-418 irreversibly inhibits LSD1 by forming a compact flavin-FAD adduct with the catalytic domain FAD, blocking the demethylation of H3K4me1/2 and H3K9me1/2 without disrupting the LSD1-GFI1B interaction. TAK-418 restores normally dysregulated brain gene expression and DNA methylation, increases H3K4me1/2/3 and H3K9me2 at the Ucp2 locus, and induces Ucp2 mRNA expression. TAK-418 rescues defective H3K4 histone modifications, normalizes adult neurogenesis, and improves recognition memory, social behavior, and cognition in rodent models. TAK-418 can be used in research related to neurodevelopmental disorders, Alzheimer's disease, and autism spectrum disorders .
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1
Roflupram
Roflupram
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1 Cited Publications
Cat. No.: HY-115383
CAS No.: 1093412-18-0
Purity:  99.45%
Target:  

Phosphodiesterase (PDE)

Research Areas:  

Neurological Disease Inflammation/Immunology

Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors .
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N-Desmethyl imatinib
N-Desmethyl imatinib
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1 Cited Publications
Cat. No.: HY-G0017
CAS No.: 404844-02-6
Synonyms: Norimatinib; Imatinib metabolite N-Desmethyl imatinib; CGP 74588
Target:  

Drug Metabolite P-glycoprotein Apoptosis Bcr-Abl

Research Areas:  

Neurological Disease Cancer

N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib shows significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) models with mild SARS-CoV-2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .
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Biotin-epoxomicin
Biotin-epoxomicin
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Cat. No.: HY-P11307
CAS No.: 1334608-28-4
Target:  

Proteasome

Research Areas:  

Cancer

Biotin-epoxomicin is a Proteasome subunit binder. Biotin-epoxomicin serves as an affinity reagent for identifying proteasomal catalytic subunits, and facilitates affinity purification of active proteasomal subunits for LC-MS identification. Biotin-epoxomicin can be used to study solid tumors derived from B16 melanoma .
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Sodium oxalate,99.5%
Sodium oxalate,99.5%
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Cat. No.: HY-Y0262B
CAS No.: 62-76-0
Synonyms: Ethanedioic acid sodium
Target:  

Biochemical Assay Reagents Mitochondrial Metabolism

Research Areas:  

Endocrinology Cancer

Sodium oxalate is an orally active dispersant and coordination agent. Sodium oxalate causes mitochondrial dysfunction. Sodium oxalate has catalytic enhancing activity. Sodium oxalate induces stable chronic kidney disease. Sodium oxalate induces highly malignant and undifferentiated breast tumors .
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Envudeucitinibum
Envudeucitinibum
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Cat. No.: HY-153701S
CAS No.: 2417135-66-9
Synonyms: Envudeucitinib; ESK-001
Target:  

JAK STAT Interleukin Related IFNAR Isotope-Labeled Compounds

Research Areas:  

Inflammation/Immunology

Envudeucitinibum (Envudeucitinib; ESK-001) is an orally active and selective TYK2 allosteric inhibitor with an IC50 range of 104-149 nM. Envudeucitinibum blocks JH1 catalytic activity by specifically binding to the JH2 domain of TYK2, thereby inhibiting downstream signaling pathways. Envudeucitinibum is used for research on plaque psoriasis, systemic lupus erythematosus, and other immune-mediated diseases .
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Microbial neutral proteinase
Microbial neutral proteinase
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Cat. No.: HY-E70004
CAS No.: 9068-59-1
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

Microbial neutral proteinase is a zinc-containing metalloproteinase mainly produced by Bacillus and fungi. Its catalytic activity is highly dependent on divalent cations, and it remains active within the pH range of 5-8. Microbial neutral proteinase can specifically cleave peptide bonds within polypeptide chains, thereby degrading macromolecular proteins into small peptides or amino acids. It can be applied in various industrial fields including food processing, brewing, detergents, and light industry .
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AANAT-IN-1
AANAT-IN-1
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Cat. No.: HY-157521
CAS No.: 3055162-52-9
Target:  

Acyltransferase

Research Areas:  

Neurological Disease Metabolic Disease

AANAT-IN-1 is an arylalkylamine N-acetyltransferase (AANAT) inhibitor with a sheep AANAT IC50 of 9.9 μM. AANAT-IN-1 binds to the active site of sheep AANAT, interacting with amino acid residues via hydrogen bonds, hydrophobic interactions, ionic interactions, and water bridges, inhibiting the enzyme's catalytic activity. AANAT-IN-1 can be used for the researches of circadian rhythm-associated neuropsychiatric conditions, seasonal affective disorder, and other diseases associated with abnormally elevated melatonin levels .
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DKI5
DKI5
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Cat. No.: HY-149922
CAS No.: 1101130-96-4
Purity:  98.12%
Target:  

LOX-1

Research Areas:  

Cardiovascular Disease Others

DKI5 is a LOX-1 inhibitor with a soybean IC50 of 22.5 μM. DKI5 binds to the active site and affects the catalytic iron center. DKI5 inhibits lipid peroxidation .
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GAPDH-IN-1
GAPDH-IN-1
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Cat. No.: HY-171036
CAS No.: 252212-58-1
Research Areas:  

Metabolic Disease

GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD +, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine .
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IGRP(206-214)
IGRP(206-214)
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Cat. No.: HY-P5489
CAS No.: 849069-99-4
Target:  

IFNAR

Research Areas:  

Metabolic Disease Inflammation/Immunology

IGRP(206-214) is a biological active peptide. IGRP(206-214) corresponds to residues 206-214 of murine islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP). IGRP(206-214) is T cells specific for proinsulin and IGRP induces diabetes in non-obese diabetic (NOD) mice .
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Multi-Leu peptide triacetate
Multi-Leu peptide triacetate
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Cat. No.: HY-P10422A
Synonyms: ML-peptide, Multi-Leucine (ML)-peptide triacetate
Target:  

Autophagy

Research Areas:  

Cancer

Multi-Leu peptide (ML-peptide) triacetate is a potent inhibitor of PACE4 (Ki=22 nM). Multi-Leu peptide triacetate can competitively bind to the active site of PACE4 by simulating the substrate sequence of PACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide triacetate can be used to study the specific mechanism of PACE4 in the development of prostate cancer .
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AD-mix-α
AD-mix-α
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Cat. No.: HY-24312
CAS No.: 153130-59-7
AD-mix-α is a mixture of organic compounds, commonly used to distinguish and identify asymmetric carbon atoms in chiral compounds. It consists of compounds containing catalytically active metals and chiral ligands. AD-mix-α is widely used in various organic synthesis reactions, such as hydrogenation, addition, and carbonylation reactions, to increase yield and reduce the formation of side reaction products. Although it has no direct application in the medical field, it plays an important role in the pharmaceutical industry and chemical research.
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Tanshinone IIA anhydride
Tanshinone IIA anhydride
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Cat. No.: HY-N10686
CAS No.: 61077-78-9
Category:  

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