139

139 Publications Verification

CAS No.: 1209500-46-8

Target:

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

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139

GsMTx4 TFA

139 Publications Verification

Cat. No.: HY-P1410A

Target:

TRP Channel Piezo Channel

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

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9

Gramicidin

9 Cited Publications

Cat. No.: HY-P0163

CAS No.: 1405-97-6

Category:

Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:

Bacterial Antibiotic

Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations.

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9

Adenosine 5′-diphosphoribose sodium

9 Cited Publications

Cat. No.: HY-100973A

CAS No.: 68414-18-6

Purity: 99.47%

Synonyms: ADP ribose sodium

Target:

TRP Channel Autophagy

Research Areas:

Metabolic Disease Endocrinology Cancer

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD ⁺) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca ²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .

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9

Flufenamic acid

9 Cited Publications

Cat. No.: HY-B1221

CAS No.: 530-78-9

Target:

COX AMPK Potassium Channel Chloride Channel Calcium Channel Parasite

Research Areas:

Inflammation/Immunology

Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K ⁺ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

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9

Adenosine 5′-diphosphoribose

9 Cited Publications

Cat. No.: HY-100973

CAS No.: 20762-30-5

Purity: 98.21%

Synonyms: ADP ribose

Target:

TRP Channel Autophagy

Research Areas:

Neurological Disease Metabolic Disease Cancer

Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD ⁺) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca ²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy .

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