9

N-Nitrosodiethylamine

9 Cited Publications

Cat. No.: HY-N7434

CAS No.: 55-18-5

Synonyms: Diethylnitrosamine; DEN; DENA

Category:

Natural Products Plants Other Families Extract Disease Research Fields Cancer

Target:

DNA/RNA Synthesis

N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

PhiKan 083

3 Cited Publications

Cat. No.: HY-108637

CAS No.: 880813-36-5

Purity: 98.93%

Target:

MDM-2/p53

Research Areas:

Cancer

PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a K_d of 167 μM. PhiKan 083 can be used for cancer research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

PhiKan 083 hydrochloride

3 Cited Publications

Cat. No.: HY-108637A

CAS No.: 1050480-30-2

Purity: 99.01%

Target:

MDM-2/p53

Research Areas:

Cancer

PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a K_d of 167 μM , and a relative binding affinity (K_d) of 150 μM in Ln229 cells .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Sapienic acid sodium

1 Cited Publications

Cat. No.: HY-130187A

CAS No.: 217477-25-3

Purity: ≥98.0%

Target:

Bacterial

Research Areas:

Infection

Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid sodium is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Sapienic acid

1 Cited Publications

Cat. No.: HY-130187

CAS No.: 17004-51-2

Target:

Bacterial

Research Areas:

Infection

Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

N-Nitrosodiethylamine-d10

Cat. No.: HY-N7434S1

CAS No.: 1219794-54-3

Synonyms: Diethylnitrosamine-d₁₀; DEN-d₁₀; DENA-d₁₀

N-Nitrosodiethylamine-d₁₀ is the deuterium labeled N-Nitrosodiethylamine . N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Trpvicin

Cat. No.: HY-165559

CAS No.: 2019994-90-0

Target:

TRP Channel

Research Areas:

Inflammation/Immunology

Trpvicin is a potent and subtype-selective TRPV3 inhibitor with IC₅₀s of 0.41 and 0.22 μM for hTRPV3-WT and hTRPV3-G573S mutant, respectively. Trpvicin exhibits minimal effects on other TRP family members (such as TRPV1/2/4/5/6, TRPA1 and TRPM8). Trpvicin inhibits the TRPV3 channel by stabilizing it in a closed state via VSLD-PD binding. Trpvicin accesses additional binding sites inside the central cavity of the G573S mutant to remodel symmetry and block the channel. Trpvicin inhibits itch and hair loss in mouse models. Trpvicin can be used for study of inflammation and immunology .

Compare

loading...