102 Results for "

cell polarization

" in MedChemExpress (MCE) Product Catalog:
Products (102)

102 Results for "cell polarization" in MCE Product Catalog:

36
Pemrametostat
Pemrametostat
0 Images
36 Publications Verification
Cat. No.: HY-101563
CAS No.: 1616392-22-3
Purity:  99.51%
Synonyms: GSK3326595; EPZ015938
Target:  

Histone Methyltransferase SARS-CoV MDM-2/p53 CDK Apoptosis

Research Areas:  

Infection Cancer

GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma .
loading...
    loading...
View All Sizes
32
L-Kynurenine sulfate
L-Kynurenine sulfate
0 Images
32 Cited Publications
Cat. No.: HY-104026B
CAS No.: 16055-80-4
Category:  

Alkaloids Human Gut Microbiota Metabolites Other Alkaloids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite Aryl Hydrocarbon Receptor

L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .
loading...
    loading...
View All Sizes
27
Laurdan
Laurdan
0 Images
27 Cited Publications
Cat. No.: HY-D0080
CAS No.: 74515-25-6
Target:  

Fluorescent Dye

Research Areas:  

Cancer

Laurdan is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound. Quantitation of generalized polarization (GP) of Laurdan can be used to identify phospholipid phase (Ex/Em = 370/440-490 nm).
loading...
    loading...
View All Sizes
27
Beta-Sitosterol (purity>98%)
Beta-Sitosterol (purity>98%)
0 Images
27 Cited Publications
Cat. No.: HY-N0171A
CAS No.: 83-46-5
Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)
Category:  

Steroids

Target:  

Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD

Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
loading...
    loading...
View All Sizes
27
Beta-Sitosterol (purity>80%)
Beta-Sitosterol (purity>80%)
0 Images
27 Cited Publications
Cat. No.: HY-N0171
CAS No.: 83-46-5
Category:  

Endogenous metabolite

Target:  

Apoptosis Endogenous Metabolite

Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
loading...
    loading...
View All Sizes
13
TMA-DPH
TMA-DPH
0 Images
13 Cited Publications
Cat. No.: HY-D0986
CAS No.: 115534-33-3
TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .
loading...
    loading...
View All Sizes
8
SKI II
SKI II
0 Images
8 Cited Publications
Cat. No.: HY-13822
CAS No.: 312636-16-1
Purity:  99.25%
Target:  

SphK Dihydroceramide Desaturase 1 (DES1) Apoptosis Reactive Oxygen Species (ROS) mTOR PERK Keap1-Nrf2

Research Areas:  

Infection Neurological Disease Cancer

SKI-II is an orally active dual-target inhibitor of SphK1/2 and DES1, with Ki values of 16 µM and 0.3 µM against SphK1 and DES1, respectively. SKI-II activates the PERK-Nrf2 antioxidant pathway by stabilizing Nrf2, and synergizes with Temozolomide (HY-17364) to induce oxidative/endoplasmic reticulum stress and cancer cell death under hypoxic conditions. In vivo, SKI-II inhibits SphK activity, promotes ceramide accumulation and apoptosis, and synergizes with Cisplatin (HY-17394) to reverse drug resistance via the ras/MAPK pathway. SKI-II reduces measles virus replication by inhibiting mTORC1 activity. SKI-II binds to VCP to induce M1 polarization, enhances host tolerance to Staphylococcus aureus infection, and exerts radioprotective effects through Nrf2 activation and accelerated DNA repair. SKI-II can be used in research related to glioblastoma, acute myeloid leukemia, gastric cancer, measles virus infection, Staphylococcus aureus infection, and acute radiation syndrome .
loading...
    loading...
View All Sizes
6
Diethyl succinate
Diethyl succinate
0 Images
6 Cited Publications
Cat. No.: HY-Y0836
CAS No.: 123-25-1
Synonyms: Diethyl Butanedioate
Category:  

Natural Products Metabolic Disease Plants Other Families Extract Disease Research Fields

Target:  

Biochemical Assay Reagents Reactive Oxygen Species (ROS)

Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings .
loading...
    loading...
View All Sizes
5
PI3K/Akt/CREB activator 1
PI3K/Akt/CREB activator 1
0 Images
5 Cited Publications
Cat. No.: HY-151527
CAS No.: 2708177-73-3
Purity:  98.64%
Target:  

Akt PI3K Epigenetic Reader Domain

Research Areas:  

Neurological Disease

PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD) .
loading...
    loading...
View All Sizes
3
Abietic acid
Abietic acid
0 Images
3 Cited Publications
Cat. No.: HY-N6871
CAS No.: 514-10-3
Category:  

Infection Colophony Ketones, Aldehydes, Acids Metabolic Disease Plants Pinaceae Extract Disease Research Fields Inflammation/Immunology

Target:  

Bacterial IKK Ferroptosis

Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .
loading...
    loading...
View All Sizes
2
Hordenine
Hordenine
0 Images
2 Cited Publications
Cat. No.: HY-N0113
CAS No.: 539-15-1
Synonyms: Ordenina; Peyocactine
Category:  

Cardiovascular Disease Alkaloids Monophenols Other Alkaloids Phenols Plants Other Families Extract Disease Research Fields

Target:  

Bacterial p38 MAPK JNK ERK Akt Interleukin Related TNF Receptor NO Synthase COX Reactive Oxygen Species (ROS) Microphthalmia Associated Transcription Factor (MITF) Wnt β-catenin Dopamine Receptor Adrenergic Receptor 5-HT Receptor Serotonin Transporter Dopamine Transporter α-synuclein

Hordenine (Ordenina; Peyocactine) is a multifunctional alkaloid with oral activity and blood-brain barrier penetration. Hordenine inhibits LPS-induced phosphorylation of p38, JNK, ERK1/2, p65, IκB, and AKT, prevents p65 nuclear translocation, and suppresses inflammatory cytokines and mediators. Hordenine promotes M2 macrophage polarization, restores blood-milk barrier integrity, alleviates oxidative stress by reducing ROS and MDA, and attenuates LPS-induced lung injury and pulmonary edema. Hordenine inhibits cAMP production, CREB phosphorylation, and MITF expression, thereby suppressing melanin synthesis in melanocytes and reconstructed epidermis. Hordenine activates the Wnt/β-catenin signaling pathway, promotes dermal papilla cell proliferation and hair shaft elongation, and accelerates hair regeneration. Hordenine activates DRD2, acts as a D3R partial agonist, α2A-AR full agonist, and 5-HT2A-R antagonist, and inhibits SERT and DAT. Hordenine inhibits α-synuclein accumulation and ameliorates motor deficits in Parkinson's disease models. Hordenine limits alcohol intake, reduces relapse drinking behavior, and modulates alcohol-induced conditioned place preference. Hordenine can be used for research on mastitis, skin pigmentation, acute lung injury, foodborne diseases, hair loss, Parkinson's disease, bacterial infections, and alcohol use disorder .
loading...
    loading...
View All Sizes
2
Beta-Sitosterol (Standard)
Beta-Sitosterol (Standard)
0 Images
2 Cited Publications
Cat. No.: HY-N0171R
CAS No.: 83-46-5
Synonyms: β-Sitosterol (Standard); 22,23-Dihydrostigmasterol (Standard))
Category:  

Cardiovascular Disease 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.