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28 Results for "

cellular adhesion

" in MedChemExpress (MCE) Product Catalog:

Products (28)

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A-286982

3 Cited Publications

Cat. No.: HY-107587

CAS No.: 280749-17-9

Purity: 99.33%

Target:

Integrin

Research Areas:

Inflammation/Immunology

A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC₅₀s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively .

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Narmafotinib

2 Cited Publications

Cat. No.: HY-145652

CAS No.: 1393653-34-3

Purity: 99.86%

Synonyms: AMP-945

Narmafotinib (AMP-945) is an orally active inhibitor of the enzyme focal adhesion kinase (FAK, K_D=0.21 nM). Narmafotinib inhibits autophosphorylation of 397Y-FAK in MDA-MB-231 cells with an IC₅₀=7 nM and exhibits low general cellular toxicity (IC₅₀=2.7 μM, MDA-MB-231 cells). Narmafotinib can be used for anti-cancer study .

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Cyclic GMP

2 Cited Publications

Cat. No.: HY-113469

CAS No.: 7665-99-8

Purity: 99.43%

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Endogenous metabolite

Target:

Endogenous Metabolite

Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .

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