935

Erastin

935 Publications Verification

Cat. No.: HY-15763

CAS No.: 571203-78-6

Purity: 99.62%

Target:

VDAC Ferroptosis Disulfidptosis

Research Areas:

Cancer

Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation .

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191

DAPI dihydrochloride

191 Cited Publications

Cat. No.: HY-D0814

CAS No.: 28718-90-3

Synonyms: 4',6-Diamidino-2-phenylindole dihydrochloride

DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).

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191

DAPI

191 Cited Publications

Cat. No.: HY-D2868

CAS No.: 47165-04-8

Synonyms: 4',6-Diamidino-2-phenylindole

DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).

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185

DAPI dilactate

185 Cited Publications

Cat. No.: HY-D1738

CAS No.: 28718-91-4

Synonyms: 4',6-Diamidino-2-phenylindole dilactate

DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .

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161

Chlorpromazine

161 Cited Publications

Cat. No.: HY-12708

CAS No.: 50-53-3

Purity: 99.75%

Target:

Dopamine Receptor Cytochrome P450 Autophagy 5-HT Receptor

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis .

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161

Chlorpromazine hydrochloride

161 Cited Publications

Cat. No.: HY-B0407A

CAS No.: 69-09-0

Target:

Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .

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139

GsMTx4

139 Cited Publications

Cat. No.: HY-P1410

CAS No.: 1209500-46-8

Target:

TRP Channel Piezo Channel

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

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139

GsMTx4 TFA

139 Cited Publications

Cat. No.: HY-P1410A

Target:

TRP Channel Piezo Channel

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

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98

Verapamil

98 Cited Publications

Cat. No.: HY-14275

CAS No.: 52-53-9

Purity: 98.96%

Synonyms: (±)-Verapamil; CP-16533-1

Target:

Calcium Channel P-glycoprotein Cytochrome P450

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

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98

Verapamil hydrochloride

98 Cited Publications

Cat. No.: HY-A0064

CAS No.: 152-11-4

Synonyms: (±)-Verapamil hydrochloride; CP-16533-1 hydrochloride

Target:

Calcium Channel P-glycoprotein Cytochrome P450

Research Areas:

Cardiovascular Disease Cancer

Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

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76

Amiloride

76 Cited Publications

Cat. No.: HY-B0285

CAS No.: 2609-46-3

Synonyms: MK-870

Target:

Sodium Channel TRP Channel Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease

Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

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76

Amiloride hydrochloride

76 Cited Publications

Cat. No.: HY-B0285A

CAS No.: 2016-88-8

Synonyms: MK-870 hydrochloride

Target:

Sodium Channel TRP Channel Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease

Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

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76

Amiloride hydrochloride dihydrate

76 Cited Publications

Cat. No.: HY-B0285B

CAS No.: 17440-83-4

Synonyms: MK-870 hydrochloride dihydrate

Target:

Sodium Channel Apoptosis TRP Channel

Research Areas:

Cardiovascular Disease Metabolic Disease

Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

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53

Streptomycin

53 Cited Publications

Cat. No.: HY-B1906

CAS No.: 57-92-1

Synonyms: Agrept; Agrimycin; Streptomycin A

Category:

Natural Products Microorganisms

Target:

Environmental Pollutants Antibiotic Bacterial

Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .

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48

Bicuculline methochloride

48 Cited Publications

Cat. No.: HY-137790

CAS No.: 38641-83-7

Purity: 99.35%

Synonyms: (-)-Bicuculline methochloride

Target:

GABA Receptor

Research Areas:

Neurological Disease

Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC₅₀ value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca ²⁺ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders .

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44

Bicuculline

44 Cited Publications

Cat. No.: HY-N0219

CAS No.: 485-49-4

Synonyms: (+)-Bicuculline

Category:

Alkaloids 500 - Internal Server Error | MedChemExpress

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