212 Results for "

chinensis

" in MedChemExpress (MCE) Product Catalog:

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Schisandrin B

12 Cited Publications

Cat. No.: HY-N0089

CAS No.: 61281-37-6

Synonyms: γ-Schisandrin; Wuweizisu B

Category:

Plant Neurological Disease Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract Disease Research Fields Cancer

Target:

Autophagy Reactive Oxygen Species (ROS)

Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

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Coptisine Sulfate

6 Cited Publications

Cat. No.: HY-N0430A

CAS No.: 1198398-71-8

Category:

Alkaloids Plant Metabolic Disease Chelidonium majus Extract Quinoline Alkaloids Disease Research Fields Papaveraceae Extract

Target:

Indoleamine 2,3-Dioxygenase (IDO) NF-κB p38 MAPK PI3K Akt Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism DNA/RNA Synthesis ROCK LDLR

Coptisine Sulfate is an orally active and brain-penetrant alkaloid found in Coptis chinensis. Coptisine Sulfate is a reversible, uncompetitive IDO inhibitor with a K_i of 5.8 μM and an IC₅₀ of 6.3 μM. Coptisine Sulfate suppresses neuroinflammation, reduces Aβ plaque burden and shows neuroprotective activity. Coptisine Sulfate shows anti-inflammation activity by blocking NF-κB, MAPK, and PI3K/Akt activation. Coptisine Sulfate inhibits cancer cells proliferation, induces DNA damage, G2/M phase cell cycle arrest, apoptosis, ROS production and mitochondrial dysfunction. Coptisine Sulfate inhibits Rho/ROCK pathway activation, reduces arrhythmia, limits cardiac injury marker release, reduces infarct size, and preserves cardiac function in rat myocardial ischemia/reperfusion models. Coptisine Sulfate downregulates HMGCR and upregulates LDLR and CYP7A1 to modulate cholesterol metabolism, reduces abnormal serum lipid levels, and promotes fecal bile acid excretion. Coptisine Sulfate be used for the research of cancer, hypercholesterolemia, Alzheimer’s disease, inflammatory disorders and cardiovascular disease .

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Schisandrin C

5 Cited Publications

Cat. No.: HY-N0690

CAS No.: 61301-33-5

Synonyms: Schizandrin-C; Wuweizisu-C

Category:

Plant Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract Disease Research Fields Cancer

Target:

Apoptosis

Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research . Schisandrin C induces cell apoptosis .

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Jatrorrhizine chloride

5 Cited Publications

Cat. No.: HY-N0740

CAS No.: 6681-15-8

Category:

Alkaloids Plant Monophenols Phenols Isoquinoline Alkaloids Ranunculaceae Extract Coptis chinensis Franch. Extract

Target:

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

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Jatrorrhizine hydroxide

5 Cited Publications

Cat. No.: HY-N0749A

CAS No.: 483-43-2

Category:

Alkaloids Plant Monophenols Phenols Isoquinoline Alkaloids Ranunculaceae Extract Coptis chinensis Franch. Extract

Target:

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

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Epiberberine chloride

5 Cited Publications

Cat. No.: HY-N0226A

CAS No.: 889665-86-5

Category:

Alkaloids Plant Neurological Disease Metabolic Disease Disease Research Fields Isoquinoline Alkaloids Ranunculaceae Extract Coptis chinensis Franch. Extract

Target:

Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species (ROS)

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and may protect against Alzheimer disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .

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Irisflorentin

4 Cited Publications

Cat. No.: HY-N0268

CAS No.: 41743-73-1

Category:

Plant Flavonoids Iridaceae Extract Disease Research Fields Inflammation/Immunology Belamcanda chinensis (Linn.) Redouté Extract Isoflavones

Target:

NO Synthase

Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

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Schisandrin

4 Cited Publications

Cat. No.: HY-N0691

CAS No.: 7432-28-2

Synonyms: Schizandrin; Schizandrol; Schizandrol-A

Category:

Plant Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract Disease Research Fields Cancer

Target:

Autophagy

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

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Leucocyanidin

3 Cited Publications

Cat. No.: HY-119580

CAS No.: 480-17-1

Purity: 98.03%

Category:

Sapindaceae Extract Litchi Chinensis Sonn. Extract Plant Flavonoids Flavanols Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

Others

Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models .

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Atractylodin

3 Cited Publications

Cat. No.: HY-N0238

CAS No.: 55290-63-6

Synonyms: Atractydin

Category:

Infection Natural Products Plant Atractylodes lancea (Thunb.) DC Extract Compositae/Asteraceae Extract Disease Research Fields

Target:

Insecticide

Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity .

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Gomisin J

3 Cited Publications

Cat. No.: HY-N0385

CAS No.: 66280-25-9

Category:

Cardiovascular Disease Plant Monophenols Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenols Phenylpropanoids Schisandraceae Extract Disease Research Fields

Target:

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .

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Schisandrol B

2 Cited Publications

Cat. No.: HY-N0692

CAS No.: 58546-54-6

Synonyms: Gomisin-A; TJN-101; Wuweizi alcohol-B

Category:

Plant Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract Disease Research Fields Cancer

Target:

Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy

Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

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Hederacolchiside A1

2 Cited Publications

Cat. No.: HY-N6950

CAS No.: 106577-39-3

Category:

Infection Triterpenes Plant Terpenoids Other Families Extract Disease Research Fields

Target:

PI3K Akt mTOR Parasite Apoptosis

Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway . Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro .

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Dichotomitin

2 Cited Publications

Cat. No.: HY-N2120

CAS No.: 88509-91-5

Category:

Plant Flavonoids Other Diseases Phenols Polyphenols Iridaceae Extract Disease Research Fields Belamcanda chinensis (Linn.) Redouté Extract Isoflavones

Target:

Reactive Oxygen Species (ROS) SOD RUNX

Dichotomitin is an isoflavonoid compound isolated from the rhizomes of Belamcanda chinensis. Dichotomitin exhibits antioxidant activity, alleviates oxidative stress, reduces intracellular reactive oxygen species (ROS) levels, and upregulates the expression of SOD1, SOD2 and CAT. Dichotomitin increases ALP activity while upregulating the expression of RUNX2, OPN and OCN. Dichotomitin has antitussive activity and helps improve symptoms of upper respiratory tract infections .

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Bifendate

2 Cited Publications

Cat. No.: HY-W018791

CAS No.: 73536-69-3

Synonyms: DDB

Target:

HBV Autophagy Cytochrome P450 Atg8/LC3 p62 P-glycoprotein

Research Areas:

Infection Cardiovascular Disease Cancer

Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .

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Pulsatilla saponin D

1 Cited Publications

Cat. No.: HY-N0834

CAS No.: 68027-15-6

Synonyms: SB365; Hederacolchiside A

Category:

Triterpenes Plant Terpenoids Pulsatilla chinensis (Bunge) Regel Extract Disease Research Fields Cancer Ranunculaceae Extract

Target:

Apoptosis

Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla chinensis, is an anti-tumor agent .

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Fraxinol

1 Cited Publications

Cat. No.: HY-N2372

CAS No.: 486-28-2

Category:

Plant Monophenols Coumarins Phenols Phenylpropanoids Other Families Extract Disease Research Fields Cancer

Target:

Cytochrome P450

Fraxinol is isolated from Lobelia chinensis .

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Sauchinone

1 Cited Publications

Cat. No.: HY-N0613

CAS No.: 177931-17-8

Category:

Saururus chinensis (Lour.) Baill. Extract Plant Terpenoids Diterpenoids Disease Research Fields Inflammation/Immunology Saururaceae Extract

Target:

NF-κB

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

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Escin IA

1 Cited Publications

Cat. No.: HY-N0554

CAS No.: 123748-68-5

Category:

Infection Aesculus hippocastanum Extract Triterpenes Plant Hippocastanaceae Extract Terpenoids Other Families Extract Disease Research Fields Cancer

Target:

HIV Protease Monoamine Oxidase

Escin IA is an oral LOXL2 inhibitor and EMT inhibitor, with selectivity for LOXL2-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions .

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Schisantherin B

1 Cited Publications

Cat. No.: HY-N0695

CAS No.: 58546-55-7

Synonyms: Gomisin-B; Wuweizi ester-B; Schisantherin-B

Category:

Plant Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract Disease Research Fields Inflammation/Immunology

Target:

PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis

Schisantherin B (Gomisin-B) is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression .

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