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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
chiral HPLC
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "chiral HPLC" in MCE Product Catalog:
Cat. No.: HY-I0169
CAS No.: 196601-69-1
Target:
Research Areas:
(R)-Amino-N-benzyl-3-methoxypropionamide is a key intermediate for the synthesis of the antiepileptic agent (R)-Lacosamide. To improve its chiral purity and chemical stability, (R)-Amino-N-benzyl-3-methoxypropionamide can react with phosphoric acid to form a phosphate salt. Detected by high performance liquid chromatography (HPLC), this phosphate salt exhibits extremely high chiral purity, with the content of the R-enantiomer reaching up to 99.37% .
Cat. No.: HY-W007978A
CAS No.: 18531-95-8
Synonyms: S-(-)-2,2-Diamino-1,1-binaphthyl
Target:
Research Areas:
(S)-[1,1'-Binaphthalene]-2,2'-diamine (S-(-)-2,2-Diamino-1,1-binaphthyl) is a chiral diamine compound and chiral template for molecularly imprinted polymers applied as chiral stationary phases for HPLC separation of DABN racemates .
Cat. No.: HY-112653
CAS No.: 98462-03-4
Synonyms: 8(S)-Hydroxyeicosatetraenoic acid
Cat. No.: HY-120460
CAS No.: 105500-09-2
Synonyms: 8(R)-Hydroxyeicosatetraenoic acid
Target:
Research Areas:
8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
Cat. No.: HY-115408
CAS No.: 107656-14-4
Synonyms: 9(R)-Hydroxyeicosatetraenoic acid
Target:
Research Areas:
9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control.1 Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
Cat. No.: HY-B0109H
CAS No.: 120279-95-0
Synonyms: (4R,6R)-L671152; (4R,6R)-MK507
Research Areas:
(4R,6R)-Dorzolamide ((4R,6R)-L671152; (4R,6R)-MK507) is a carbonic anhydrase II (CAII) inhibitor and the undesired chiral enantiomer of Dorzolamide. (4R,6R)-Dorzolamide inhibits CAII isoenzymes, thereby modulating the rate of aqueous humor formation. (4R,6R)-Dorzolamide serves as a stereoisomeric reference standard in chiral HPLC separation studies. (4R,6R)-Dorzolamide can be used for research on ocular hypertension and glaucoma .
Cat. No.: HY-L903
5,282 compounds
Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function. 3-dimensionality (3D) diversity is pivotal because the molecular shape is one of the most important factors in molecular recognition by a biomolecule. There is a developing appreciation that 3D fragments could offer opportunities that are not provided by 2D fragments.
MCE 3D Diverse Fragment Library consists of 5,400 non-flat fragment-like molecules (average Fsp3 value 0.58). More than 4,700 fragment compounds contain at least one chiral center in the structure. The key concepts that underlie the library design were 3D shape, structural diversity, reactive functionality and fragment-like. This 3D Diverse Fragment Library brings higher fragment hit optimization and increases the likelihood to find innovative hits in FBDD.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
