21

Lithocholic acid

21 Publications Verification

Cat. No.: HY-B0172

CAS No.: 434-13-9

Synonyms: 3α-Hydroxy-5β-cholanic acid

Category:

Human Gut Microbiota Metabolites Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Autophagy Endogenous Metabolite Apoptosis FXR

Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist .

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9

Glycochenodeoxycholic acid

9 Cited Publications

Cat. No.: HY-N2334

CAS No.: 640-79-9

Synonyms: Chenodeoxycholylglycine

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Endogenous Metabolite Caspase Apoptosis BCL6 Interleukin Related STAT

Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

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9

Glycochenodeoxycholic acid sodium salt

9 Cited Publications

Cat. No.: HY-N2334A

CAS No.: 16564-43-5

Synonyms: Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase

Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

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6

Taurolithocholic acid

6 Cited Publications

Cat. No.: HY-113308

CAS No.: 516-90-5

Purity: 98.06%

Target:

Calcium Channel Ferroptosis PI3K Akt HBV Reactive Oxygen Species (ROS)

Research Areas:

Cardiovascular Disease Infection Inflammation/Immunology

Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis (Ferroptosis), viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .

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6

Taurolithocholic acid sodium salt

6 Cited Publications

Cat. No.: HY-113308A

CAS No.: 6042-32-6

Purity: 99.81%

Category:

Animals Metabolic Disease Disease Research Fields Steroids

Target:

Calcium Channel Ferroptosis PI3K Reactive Oxygen Species (ROS) Akt HBV

Taurolithocholic acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .

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5

Glycodeoxycholic acid

5 Cited Publications

Cat. No.: HY-125731

CAS No.: 360-65-6

Purity: 99.08%

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite STAT Autophagy

Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

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2

Hyocholic acid

2 Cited Publications

Cat. No.: HY-121238

CAS No.: 547-75-1

Purity: 99.46%

Target:

FXR G protein-coupled Bile Acid Receptor 1

Research Areas:

Metabolic Disease

Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes .

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2

Ursocholic acid

2 Cited Publications

Cat. No.: HY-113212

CAS No.: 2955-27-3

Purity: 99.91%

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite Apoptosis

Ursocholic acid, a bile acid present in mammalian bile, is converted to deoxycholic acid (UDC) by the mouse intestinal flora. Ursocholic acid acts as a gallstone dissolving agent in the liver through anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling, Ursocholic acid also has favorable effects on bones in patients with chronic cholestasis .

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1

3b-Hydroxy-5-cholenoic acid

1 Cited Publications

Cat. No.: HY-113315

CAS No.: 5255-17-4

Purity: 99.93%

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite

3β-Hydroxy-5-cholenoic acid is a steroidal monohydroxy bile acid and serves as a substrate for sulfation reactions. It is applicable to the research of extrahepatic biliary atresia and recurrent intrahepatic cholestasis of pregnancy .

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1

Fluorofenidone

1 Cited Publications

Cat. No.: HY-121246

CAS No.: 848353-85-5

Purity: 99.78%

Synonyms: AKF-PD

Target:

ACSL Family NF-κB ERK TGF-beta/Smad

Research Areas:

Inflammation/Immunology Cancer

Fluorofenidone (AKF-PD) is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

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1

Tauro-ω-muricholic acid sodium

1 Cited Publications

Cat. No.: HY-136066

CAS No.: 2456348-84-6

Purity: 97.80%

Synonyms: TωMCA sodium

Target:

Endogenous Metabolite

Research Areas:

Metabolic Disease

Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies

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1

Taurolithocholic acid-d4

1 Cited Publications

Cat. No.: HY-113308S1

CAS No.: 2410279-96-6

Taurolithocholic acid-d₄ is deuterium labeled Taurolithocholic acid. Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .

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1

Taurolithocholic acid-d4 sodium

1 Cited Publications

Cat. No.: HY-113308AS

CAS No.: 2410279-97-7

Purity: 99.4%

Taurolithocholic acid-d₄ (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .

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D-chiro-Inositol

Cat. No.: HY-N3021

CAS No.: 643-12-9

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite NF-κB TNF Receptor FOXO Microtubule/Tubulin

D-chiro-Inositol is a stereoisomer of inositol that exhibits activities such as improving glucose metabolism, anti-tumor effects, anti-inflammatory properties, and antioxidant activity. D-chiro-Inositol effectively alleviates cholestasis by enhancing bile acid secretion and reducing oxidative stress. D-chiro-Inositol improves insulin resistance, lowers hyperglycemia and circulating insulin levels, reduces serum androgen levels, and ameliorates some metabolic abnormalities associated with X syndrome by mimicking the action of insulin. Additionally, D-chiro-Inositol can induce a reduction in pro-inflammatory factors (such as Nf-κB) and cytokines (such as TNF-α), thereby exerting anti-inflammatory effects. D-chiro-Inositol may be used in the study of liver cirrhosis, breast cancer, type 2 diabetes, and polycystic ovary syndrome .

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Maralixibat chloride

Cat. No.: HY-16747

CAS No.: 228113-66-4

Synonyms: SHP625 chloride; LUM001 chloride; Lopixibat chloride

Target:

Apical Sodium-Dependent Bile Acid Transporter

Research Areas:

Metabolic Disease

Maralixibat (SHP625) chloride is an orally active ileal bile acid transporter (IBAT) inhibitor. Maralixibat chloride can be used for the research of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia .

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Lithocholic acid (Standard)

Cat. No.: HY-B0172R

CAS No.: 434-13-9

Synonyms: 3α-Hydroxy-5β-cholanic acid (Standard)

Category:

Human Gut Microbiota Metabolites Microorganisms Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Reference Standards Autophagy Endogenous Metabolite Apoptosis FXR

Lithocholic acid (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist .

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Estradiol 17-(β-D-Glucuronide) sodium

Cat. No.: HY-129987

CAS No.: 15087-02-2

Purity: 99.46%

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:

Endogenous Metabolite P-glycoprotein

Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) sodium is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) sodium regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) sodium induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) sodium can be used in studies related to intrahepatic cholestasis .

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Estradiol 17-(β-D-Glucuronide)

Cat. No.: HY-W353102

CAS No.: 1806-98-0

Category:

Monophenols Metabolic Disease Phenols Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:

Endogenous Metabolite P-glycoprotein

Estradiol 17-(β-D-Glucuronide) is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) can be used in studies related to intrahepatic cholestasis .

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Hirudin (54-65)

Cat. No.: HY-P1636

CAS No.: 113274-56-9

Target:

Thrombin YAP Calcium Channel

Research Areas:

Metabolic Disease

Hirudin (54-65) is a thrombin antagonist and YAP suppressor with anticoagulatory properties.Hirudin (54-65) blocks thrombin's anion binding site, acts on soluble and thrombus-bound thrombin.Hirudin (54-65) suppresses thrombin-induced profibrotic YAP activity, reduces YAP expression, nuclear translocation, and downstream effector signaling in vascular endothelial cells.Hirudin (54-65) ameliorates obstructive cholestasis, attenuates liver fibrosis symptoms, fibrosis-associated angiogenesis, and endothelial-to-mesenchymal transition.Hirudin (54-65) reduces liver inflammation and tissue hypoxia.Hirudin (54-65) promotes extracellular calcium influx through L-type calcium channels in canine coronary artery smooth muscle, mediates contraction.Hirudin (54-65) induces endothelium-independent contraction of canine coronary arterial segments; this response is not affected by indomethacin pretreatment.Hirudin (54-65) can be used for the research of liver obstructive cholestasis, liver fibrosis .

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Licraside

Cat. No.: HY-N6987

CAS No.: 29913-71-1

Category:

Flavonoids Chalcones Phenols Polyphenols 500 - Internal Server Error | MedChemExpress

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