76

Atorvastatin calcium hydrate

76 Publications Verification

Cat. No.: HY-112490

CAS No.: 344423-98-9

Purity: 99.64%

Target:

HMG-CoA Reductase (HMGCR)

Research Areas:

Cardiovascular Disease Others

Atorvastatin calcium salt trihydrate is a drug belonging to the statin class of drugs used to lower blood cholesterol levels. Atorvastatin calcium salt trihydrate has unique chemical properties that make it an effective tool in controlling high levels of low-density lipoprotein (LDL) cholesterol and triglycerides in the body, reducing the risk of heart attack and stroke. Atorvastatin calcium salt trihydrate works by inhibiting HMG-CoA reductase, the enzyme responsible for producing cholesterol in the liver.

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47

Lovastatin

47 Cited Publications

Cat. No.: HY-N0504

CAS No.: 75330-75-5

Synonyms: Mevinolin

Category:

Microorganisms Ketones, Aldehydes, Acids Disease Research Fields Cancer

Target:

HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis

Lovastatin (Mevinolin) is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

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30

Rosuvastatin Sodium

30 Cited Publications

Cat. No.: HY-17504B

CAS No.: 147098-18-8

Synonyms: ZD 4522 Sodium; X-Plended Sodium; Crestor Sodium

Target:

HMG-CoA Reductase (HMGCR) Potassium Channel Autophagy Bacterial

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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30

Rosuvastatin Calcium

30 Cited Publications

Cat. No.: HY-17504

CAS No.: 147098-20-2

Synonyms: Rosuvastatin hemicalcium; ZD 4522 Calcium

Target:

HMG-CoA Reductase (HMGCR) Autophagy Potassium Channel Bacterial

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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30

Rosuvastatin

30 Cited Publications

Cat. No.: HY-17504A

CAS No.: 287714-41-4

Synonyms: ZD 4522

Target:

HMG-CoA Reductase (HMGCR) Autophagy Potassium Channel Bacterial

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks hERG current with an IC₅₀ of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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18

Pentagalloylglucose

18 Cited Publications

Cat. No.: HY-N0527

CAS No.: 14937-32-7

Synonyms: Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose

Category:

Infection Anti-aging Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:

JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species (ROS) E1/E2/E3 Enzyme

Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

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6

YM-53601

6 Cited Publications

Cat. No.: HY-100313A

CAS No.: 182959-33-7

Purity: 98.23%

Target:

Farnesyl Transferase HCV

Research Areas:

Infection Metabolic Disease

YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

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4

Campesterol

4 Cited Publications

Cat. No.: HY-N1459

CAS No.: 474-62-4

Category:

Endogenous metabolite

Target:

Endogenous Metabolite

Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

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2

Cerivastatin sodium

2 Cited Publications

Cat. No.: HY-109523

CAS No.: 143201-11-0

Purity: 99.84%

Target:

HMG-CoA Reductase (HMGCR) Ferroptosis

Research Areas:

Cardiovascular Disease Cancer

Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .

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2

Lapaquistat

2 Cited Publications

Cat. No.: HY-14925

CAS No.: 189059-71-0

Purity: 99.81%

Synonyms: T-91485

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Drug Metabolite

Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy .

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