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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
185 Results for "
chromosomal
" in MedChemExpress (MCE) Product Catalog:
Products (185)
185 Results for "chromosomal" in MCE Product Catalog:
22
22 Publications Verification
Target:
Research Areas:
SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor .
10
10
10 Cited Publications
Synonyms: 1,10-Phenanthroline monohydrate
7
Target:
Research Areas:
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys 496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
4
Target:
4
4 Cited Publications
Target:
Research Areas:
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .
3
2
2 Cited Publications
Cat. No.: HY-D1746
CAS No.: 162303-59-5
Synonyms: EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
2
2 Cited Publications
Cat. No.: HY-W127705
CAS No.: 4213-45-0
2
2 Cited Publications
Cat. No.: HY-P70332
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMGB2; High Mobility Group Protein 2; Prev. HMG2; HMG-2; High Mobility Group Protein B2; High-Mobility Group Box 2; High Mobility Group Box 2; High-Mobility Group (Nonhistone chromosomal) Protein 2
Species:
Human
Source:
HEK293
1
1 Cited Publications
Research Areas:
Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling .
1
1 Cited Publications
Target:
Research Areas:
FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms .
1
1 Cited Publications
YX-2-107 is a PROTAC (IC50= 4.4 nM) that selectively degrades CDK6. YX-2-107 effectively inhibits RB phosphorylation and FOXM1 expression in vitro and inhibits the development of Ph + ALL in rats. YX-2-107 can be used in the study of Ph chromosome-positive (Ph +) acute lymphoblastic leukemia (ALL) .
1
1 Cited Publications
KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells .
1
1 Cited Publications
Research Areas:
UMK57 is a MCAK activator and kinetochore-microtubule destabilizer. UMK57 enhances MCAK-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors .
1
1
1 Cited Publications
Cat. No.: HY-P79315
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMGN1; Non-Histone chromosomal Protein HMG-14; Prev. HMG14; MGC104230; High Mobility Group Nucleosome-Binding Domain-Containing Protein 1; MGC117425; High-Mobility Group (Nonhistone chromosomal) Protein 14; FLJ27265; High-Mobility Group Nucleosome Binding
Species:
Human
Source:
E. coli
1
1 Cited Publications
Target:
Research Areas:
BAY-320 is a selective and ATP-competitive Bub1 inhibitor that inhibits the kinase activity of Bub1 with an IC50 of 680 nM. BAY-320 inhibits endogenous Bub1-mediated Sgo1 localization. BAY-320 affects cellular mitotic chromosome arrangement and spindle assembly. BAY-320 inhibits cell proliferation. BAY-320 can be used in the study of cancer such as ovarian cancer and cervical cancer .
1
1 Cited Publications
Cat. No.: HY-N6739
CAS No.: 26048-05-5
1
1 Cited Publications
Target:
Research Areas:
NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity (IC50=47 nM; KD=80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism . NVS-CECR2-1 is a chemical probe.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
