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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
chronic toxicity
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "chronic toxicity" in MCE Product Catalog:
15
15 Publications Verification
Cat. No.: HY-B0199A
CAS No.: 116680-01-4
Synonyms: RS 61443 hydrochloride; TM-MMF hydrochloride
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10 Cited Publications
Cat. No.: HY-116282C
CAS No.: 9011-18-1
Synonyms: DSS (MW 35000-45000); DXS (MW 35000-45000)
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Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a polymer of dehydrated glucose with a molecular weight of approximately 35000-45000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a potent inducer of colitis. Dextran sulfate sodium salt (DSS) (MW 35000-45000) can be used to induce model acute colitis, chronic colitis, and colitis-related colon cancer. Dextran sulfate sodium salt (DSS) (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium .
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Quinones Plant Other Diseases Other Families Extract Disease Research Fields Naphthalene Quinones Alkanna cappadocica Extract
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1 Cited Publications
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1 Cited Publications
Cat. No.: HY-B0199S
CAS No.: 1132748-21-0
Cat. No.: HY-P99488
CAS No.: 2574591-89-0
Synonyms: JSP-191; AMG-191
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Cat. No.: HY-174864
CAS No.: 3100147-70-1
JP-163-16 is a NF-κB RelA/p65 PROTAC degrader that recruits CRBN. JP-163-16 selectively induces RelA/p65 degradation via the ubiquitin-proteasome pathway, exerts cytotoxicity and induces apoptosis in cancer cells, while showing low toxicity to non-malignant lymphocytes. JP-163-16 can be used for the research of chronic lymphocytic leukemia, triple-negative breast cancer and multiple myeloma .
Cat. No.: HY-B2042
CAS No.: 23184-66-9
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Butachlor is defined as a commonly used acetanilide herbicide that exhibits varying levels of chronic toxicity to microalgae and acute toxicity to aquatic organisms. Butachlor butachlor adversely affected the normal reproductive success of zebrafish .
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Plant Metabolic Disease Lipids Other Families Extract Endogenous metabolite Disease Research Fields
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Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg .
Cat. No.: HY-P991224
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Cat. No.: HY-P991200
Cat. No.: HY-B0199R
CAS No.: 128794-94-5
Synonyms: RS 61443 (Standard); TM-MMF (Standard)
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Cat. No.: HY-159007
CAS No.: 58213-75-5
Synonyms: R,S-1,3-Butanediol acetoacetate diester
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Pyroptosis NF-κB NOD-like Receptor (NLR) Caspase Apoptosis Autophagy Reactive Oxygen Species (ROS) Oxidative Phosphorylation Interleukin Related
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
BD-AcAc2 (R,S-1,3-Butanediol acetoacetate diester) is an orally active, CNS-penetrant antiepileptic agent. BD-AcAc2 inhibits NF-κB, NLRP3 inflammasome, caspase-1/3, pyroptosis, apoptosis, and enhances autophagy. BD-AcAc2 exhibits antioxidant activity by modulating ROS, MDA, SOD, and GSH levels, and alleviates oxidative stress. BD-AcAc2 mitigates chronic colitis, counteracts Dextran Sodium Sulfate (DSS)-induced pathology, protects against central nervous system oxygen toxicity and acute lung injury, and exhibits anti-seizure efficacy. BD-AcAc2 can be used for the research of colitis, sarcopenia, acute lung injury, seizure, and obesity .
Cat. No.: HY-B2042R
CAS No.: 23184-66-9
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Butachlor (Standard) is the analytical standard of Butachlor. This product is intended for research and analytical applications. Butachlor is defined as a commonly used acetanilide herbicide that exhibits varying levels of chronic toxicity to microalgae and acute toxicity to aquatic organisms. Butachlor butachlor adversely affected the normal reproductive success of zebrafish.
Cat. No.: HY-179247
BCR-ABL1-IN-2 (compound 8) is a potent BCR-ABL1 tyrosine kinase inhibitor. BCR-ABL1-IN-2 exhibits activity in Imatinib (HY-15463) resistant K562/DOX cells with LC50 of 5.29 μM. BCR-ABL1-IN-2 shows no significant toxicity in nontumor cells. BCR-ABL1-IN-2 can be used for chronic myeloid leukemia research .
Cat. No.: HY-177849
Synonyms: Amphotericin B liposome
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Liposomal Amphotericin B (Amphotericin B liposome) is a liposomal formulation of Amphotericin B (HY-B0221) that can cross the blood-brain barrier. Liposomal Amphotericin B binds to fungal cell walls and releases Amphotericin B to bind Ergosterol (HY-N0181), inducing pore formation, ion leakage, and fungal cell death. Liposomal Amphotericin B exhibits fungicidal activity against a broad spectrum of fungal pathogens, also shows activity against Leishmania, and the liposomal formulation has lower acute and chronic toxicity as well as a lower risk of fungal resistance .
Carbarsone, also known as p-ureidobenzenearsonic acid, is historically used as an amebicide in human and veterinary medicine and extensively employed in poultry and swine feed, often in combination with antibiotics to prevent conditions like blackhead in turkeys. It exhibits relatively low acute toxicity, prompting investigations into its safety for food additives under the Federal Food, Drug, and Cosmetic Act. Studies aimed at assessing its potential carcinogenicity in laboratory animals have shown negative evidence similar to other arsanilic acid derivatives, suggesting minimal risk under chronic ingestion conditions. Metabolically, carbarsone is converted to arsanilic acid, which has been observed in preliminary studies involving dogs at high doses .
Cat. No.: HY-B0199AS
Synonyms: RS 61443-d4 hydrochloride; TM-MMF-d4 hydrochloride
Cat. No.: HY-162572
CAS No.: 13456-08-1
Bitipazone, diacetylbis(piperidinethyl)thiourea cysteine ester (I), has potent anticoccidial activity. Bitipazone showed significant efficacy and good tolerability in rabbits and turkeys, and in chronic toxicity tests, bitipazone was tolerated in turkeys at concentrations below 90 ppm in feed. Pharmacokinetic studies show that bitipazone is eliminated slowly from the blood and organs of these animal species .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
