11

GSK4112

11 Publications Verification

Cat. No.: HY-14414

CAS No.: 1216744-19-2

Purity: 99.87%

Synonyms: SR6452

Target:

REV-ERB Apoptosis

Research Areas:

Metabolic Disease

GSK4112 (SR6452) is a Rev-erbα agonist with an EC₅₀ value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways .

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8

Clorgyline hydrochloride

8 Cited Publications

Cat. No.: HY-14197A

CAS No.: 17780-75-5

Purity: 99.92%

Synonyms: M&B 9302 hydrochloride

Target:

Monoamine Oxidase 5-HT Receptor Bcl-2 Family

Clorgyline hydrochloride (M&B 9302 hydrochloride) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline hydrochloride regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline hydrochloride induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline hydrochloride is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity .

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8

Clorgyline

8 Cited Publications

Cat. No.: HY-14197

CAS No.: 17780-72-2

Purity: 99.76%

Synonyms: M&B 9302

Target:

Monoamine Oxidase 5-HT Receptor Bcl-2 Family

Research Areas:

Neurological Disease Metabolic Disease Cancer

Clorgyline (M&B 9302) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity .

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8

PF-670462

8 Cited Publications

Cat. No.: HY-15490A

CAS No.: 950980-98-0

Target:

Casein Kinase

Research Areas:

Neurological Disease

PF-670462 is a selective CKI ε/δ inhibitor. PF-670462 effectively regulates the phase of the circadian rhythm .

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5

Saclofen

5 Cited Publications

Cat. No.: HY-100813

CAS No.: 125464-42-8

Purity: 99.70%

Target:

GABA Receptor

Research Areas:

Neurological Disease Inflammation/Immunology

Saclofen is an orally active and a competitive GABA_B receptor antagonist with an IC₅₀ of 7.8 μM. Saclofen has weak antagonistic effects on GABA_B1b and GABA_B2 heterodimeric recombinant receptors. Saclofen inhibits the binding of Baclofen (HY-B0007) to rat cerebellar membranes and blocks Baclofen-induced circadian phase shifts, and exhibits anti-inflammatory and analgesic effects in rats .

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4

KS15

4 Cited Publications

Cat. No.: HY-115672

CAS No.: 1033781-20-2

Purity: 99.46%

Target:

Cryptochrome

Research Areas:

Cancer

KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC₅₀=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity .

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4

Prolylleucine

4 Cited Publications

Cat. No.: HY-112173

CAS No.: 61596-47-2

Purity: 99.85%

Synonyms: Z-Pro-D-Leu-OH

Target:

Inhibitory Antibodies

Research Areas:

Cardiovascular Disease Neurological Disease

Prolylleucine (Z-Pro-D-Leu) is a dipeptide containing branched-chain amino acids. Prolylleucine (Z-Pro-D-Leu) can affect the circadian rhythms and behaviour of animals .

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3

Cytosine

3 Cited Publications

Cat. No.: HY-I0626

CAS No.: 71-30-7

Category:

Natural Products Microorganisms Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. Cytosine can be used in cancer research .

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2

KL001

2 Cited Publications

Cat. No.: HY-108468

CAS No.: 309928-48-1

Purity: 99.68%

Target:

Cryptochrome

Research Areas:

Metabolic Disease

KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis .

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2

CLK8

2 Cited Publications

Cat. No.: HY-148765

CAS No.: 898920-65-5

Purity: 98.06%

Target:

Cryptochrome

Research Areas:

Metabolic Disease Cancer

CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms .

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2

(E/Z)-GO289

2 Cited Publications

Cat. No.: HY-115519

CAS No.: 694522-87-7

Purity: 98.98%

Target:

Casein Kinase

Research Areas:

Cancer

(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC₅₀=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function .

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2

KL201

2 Cited Publications

Cat. No.: HY-134194

CAS No.: 302939-48-6

Purity: 98.18%

Target:

Cryptochrome

Research Areas:

Metabolic Disease

KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues .

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2

KL044

2 Cited Publications

Cat. No.: HY-119506

CAS No.: 1801856-93-8

Purity: 99.05%

Target:

Cryptochrome

Research Areas:

Metabolic Disease

KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC₅₀ value of 7.32, leading to the extension of the circadian period and repression of Per2 activity .

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1

FT709

1 Cited Publications

Cat. No.: HY-145967

CAS No.: 2413991-74-7

Purity: 98.03%

Target:

Deubiquitinase Mitosis

Research Areas:

Cancer

FT709 is a potent and selective USP9X inhibitor, an IC₅₀ of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms .

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1

Tasimelteon

1 Cited Publications

Cat. No.: HY-14803

CAS No.: 609799-22-6

Purity: 99.68%

Synonyms: BMS-214778; VEC-162

Target:

Melatonin Receptor

Research Areas:

Neurological Disease Endocrinology

Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) .

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1

Neuropeptide Y (3-36) (human, rat)

1 Cited Publications

Cat. No.: HY-P2543

CAS No.: 150138-78-6

Target:

Neuropeptide Y Receptor

Research Areas:

Cardiovascular Disease Neurological Disease

Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides ^[1] ^[2].

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1

5-Methoxytryptophol

1 Cited Publications

Cat. No.: HY-113440

CAS No.: 712-09-4

Purity: 99.95%

Category:

Alkaloids Neurological Disease Endogenous metabolite Disease Research Fields Indole Alkaloids

Target:

Melatonin Receptor ERK TNF Receptor Interleukin Related MMP Endogenous Metabolite

5-Methoxytryptophol is a 5-methoxyindole alcohol structurally homologous to Melatonin (HY-B0075). It is secreted by the mammalian pineal gland and exhibits an inverse circadian rhythm. 5-Methoxytryptophol regulates bone metabolism by activating the ERK1/2 pathway. It reduces the levels of pro-inflammatory cytokines TNF-α and IL-1β, as well as proteolytic enzymes MMP-1 and MMP-2, in serum and dental pulp tissues, thereby ameliorating acute pulpitis. 5-Methoxytryptophol induces rapid sleep in mice, while high doses cause respiratory depression and death. 5-Methoxytryptophol. 5-Methoxytryptophol can be used in studies related to acute pulpitis, hypnosis, and bone metabolism .

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Delta (Phospho) Sleep Inducing Peptide

Cat. No.: HY-P3819

CAS No.: 70754-23-3

Synonyms: DSIP-P

Target:

Inhibitory Antibodies

Research Areas:

Neurological Disease

Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats .

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Tripeptide-32

Cat. No.: HY-P5244

CAS No.: 1185583-20-3

Target:

Inhibitory Antibodies

Research Areas:

Metabolic Disease

Tripeptide-32 is a bioactive peptide that targets the PER1 gene. Tripeptide-32 can regulate circadian rhythms and stimulate the synthesis of cellular repair proteins, with anti-aging activity .

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