14

N-Acetyl-L-cysteine ethyl ester

14 Publications Verification

Cat. No.: HY-134495

CAS No.: 59587-09-6

Purity: 98.26%

Synonyms: N-Acetylcysteine ethyl ester; NACET

Target:

Reactive Oxygen Species (ROS)

Research Areas:

Metabolic Disease

N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H₂S) and can be used as an H₂S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant .

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12

5-Methyltetrahydrofolic acid

12 Cited Publications

Cat. No.: HY-113046

CAS No.: 134-35-0

Purity: 99.77%

Synonyms: 5-Methyl THF; 5-MTHF

Category:

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .

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8

Molidustat

8 Cited Publications

Cat. No.: HY-12654

CAS No.: 1154028-82-6

Purity: 98.58%

Synonyms: BAY 85-3934

Target:

HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cardiovascular Disease

Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC₅₀ values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia .

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3

Baminercept

3 Cited Publications

Cat. No.: HY-P99459

CAS No.: 909110-25-4

Synonyms: BG 9924; TT-47

Baminercept (BG 9924; TT-47) is an Ig fusion protein targeting the lymphotoxin β receptor (LTβR). Baminercept effectively regulates subsets of circulating immune cells by inhibiting LIGHT, LT-α1β2 and their receptors. Baminercept also increases blood lymphocyte counts and reduces plasma CXCL13 levels. Baminercept carries a high risk of hepatotoxicity. Baminercept can be used in research on rheumatoid arthritis and primary Sjögren's syndrome .

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3

Evolocumab

3 Cited Publications

Cat. No.: HY-P9930

CAS No.: 1256937-27-5

Synonyms: AMG 145

Target:

NF-κB Ser/Thr Protease Toll-like Receptor (TLR)

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H₂O₂-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation .

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2

Zymosterol

2 Cited Publications

Cat. No.: HY-114297

CAS No.: 128-33-6

Purity: 99.47%

Category:

Endogenous metabolite Steroids

Target:

Endogenous Metabolite

Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell .

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2

ML604086

2 Cited Publications

Cat. No.: HY-124416

CAS No.: 850330-18-6

Purity: 99.80%

Target:

CCR

Research Areas:

Inflammation/Immunology Endocrinology

ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca ²⁺ concentrations .

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2

Omeprazole sulfone

2 Cited Publications

Cat. No.: HY-G0007

CAS No.: 88546-55-8

Synonyms: Omeprazole sulphone

Target:

Drug Metabolite Cytochrome P450 Aryl Hydrocarbon Receptor

Research Areas:

Inflammation/Immunology

Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

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