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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
cofilin
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "cofilin" in MCE Product Catalog:
111
Target:
24
Category:
Alkaloids Plant Narcissus tazetta Linn. var. chinensis M.Roemer Extract Amaryllidaceae Extract Disease Research Fields Isoquinoline Alkaloids Cancer Agricultural Research
Target:
Target:
Research Areas:
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells .
Cat. No.: HY-170781
CAS No.: 3099003-91-2
Target:
Research Areas:
MDI-114215 (compound 85) is an allosteric LIMK1/2 dual inhibitor with good in vivo tolerance. MDI-114215 can inhibit cofilin phosphorylation in mouse brain region-induced pluripotent stem cells (iPSCs), which can be used for Fragile X Syndrome (FXS) research .
Cat. No.: HY-P5455
Target:
Research Areas:
OXA-06 hydrochloride is an ATP-competitive ROCK inhibitor that blocks anchorage-dependent growth and invasion of non-small cell lung cancer cell lines. OXA-06 hydrochloride inhibits cofilin phosphorylation but does not stimulate apoptosis .
Cat. No.: HY-16563R
CAS No.: 29477-83-6
Synonyms: Lycoricidinol (Standard)
Category:
Alkaloids Plant Narcissus tazetta Linn. var. chinensis M.Roemer Extract Amaryllidaceae Extract Isoquinoline Alkaloids
Target:
Cat. No.: HY-174229
Target:
Research Areas:
SM311 (Compound 10), a chemical probe, is a potent selective irreversible LIMK1 inhibitor (EC50=0.045 μM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion .
Cat. No.: HY-178122
Research Areas:
THNAN69 is a PROTAC degrader targeting LIMK2, which efficiently degrades ectopically expressed EGFP-LIMK2 in live HuCCT1 cells with a DC50 of 1 nM. THNAN69 induces isoform-specific ubiquitin-mediated degradation of LIMK2 by recruiting the CRBN E3 ligase, forming a stable ternary complex with LIMK2 and CRBN; this degradation process depends on the activity of cullin-RING ligase. THNAN69 does not reduce phosphorylated cofilin levels, as LIMK1 can compensate for the loss of LIMK2; it also stimulates compensatory activation of the Rho signaling pathway including PAK1/2 and ROCK1/2. THNAN69 serves as a selective chemical probe for dissecting the LIMK2 isoform-dependent biological mechanisms. THNAN69 can be used in the research of cholangiocellular carcinoma and acute lymphoblastic leukemia .
Cat. No.: HY-RS02568
Target:
Research Areas:
CFL1 Human Pre-designed siRNA Set A contains three designed siRNAs for CFL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-E70841
Target:
Research Areas:
LIM kinase 2 (LIMK2) is a serine/threonine and tyrosine kinases. LIMK2 plays a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule turnover, especially through the phosphorylation of cofilin, an actin depolymerising factor. LIMK2 Recombinant Human Active Protein Kinase is a recombinant LIMK2 protein that can be used to study LIMK2-related functions .
Cat. No.: HY-164374
CAS No.: 445007-59-0
AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways .
Cat. No.: HY-P74234
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CFL2; CDNA, FLJ94864, Homo Sapiens cofilin 2 (Muscle) (CFL2), MRNA; cofilin 2; cofilin 2 (Muscle), Isoform CRA_c; NEM7; cofilin 2 (Muscle), Isoform CRA_a; Nemaline Myopathy Type 7; cofilin, Muscle Isoform; cofilin 2 (Muscle); cofilin Isoform; cofilin-2
Species:
Human
Source:
E. coli
Cat. No.: HY-P810609
Synonyms: 18 kDa phosphoprotein;
CFL 1;
CFL;
CFL1;
COF1_HUMAN;
cofilin 1;
cofilin 1 non muscle;
cofilin;
cofilin non muscle isoform;
cofilin-1;
epididymis secretory protein Li 15;
HEL-S-15;
non-muscle isoform;
p18
Cat. No.: HY-P81566
Synonyms: 18 kDa phosphoprotein antibody;
CFL 1 antibody;
CFL antibody;
CFL1 antibody;
COF1_HUMAN antibody;
cofilin 1 antibody;
cofilin 1 non muscle antibody;
cofilin antibody;
cofilin non muscle isoform antibody;
cofilin-1 antibody;
epididymis secretory protein Li 15 antibody;
HEL-S-15 antibody;
non-muscle isoform antibody;
p18 antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
