67

Ilomastat

67 Publications Verification

Cat. No.: HY-15768

CAS No.: 142880-36-2

Purity: 98.39%

Synonyms: GM6001; Galardin

Target:

MMP

Research Areas:

Cancer

Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC₅₀s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a K_i of 0.4 nM for human skin fibroblast collagenase (MMP-1).

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31

Taxifolin

31 Cited Publications

Cat. No.: HY-N0136

CAS No.: 480-18-2

Synonyms: (+)-Dihydroquercetin; (+)-Taxifolin

Category:

Flavanonols Flavonoids Anti-aging Phenols Polyphenols Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:

TNF Receptor Free Radical Scavengers Autophagy Tyrosinase

Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

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22

Collagenase IV, Clostridium histolytica

22 Cited Publications

Cat. No.: HY-E70005D

CAS No.: 9001-12-1

Synonyms: collagenase, Type IV

Target:

MMP

Research Areas:

Others

Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin.

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21

Collagenase, Type I

21 Cited Publications

Cat. No.: HY-E70005A

CAS No.: 9001-12-1

Synonyms: EC 3.4.24.3

Target:

MMP

Research Areas:

Others

Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .

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16

Collagenase, Type II

16 Cited Publications

Cat. No.: HY-E70005B

CAS No.: 9001-12-1

Target:

MMP

Research Areas:

Others

Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

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9

MMP-2 Protein, Human (HEK293)

9 Cited Publications

Cat. No.: HY-P73296

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: MMP2; Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV collagenase); Prev. CLG4A; collagenase Type IV-A; Prev. CLG4; Neutrophil Gelatinase; TBE-1; 72 KDa Gelatinase; MMP-2; Gelatinase A; 72 KDa Type IV collagenase; MMP-II; Matrix Metalloproteinase-2; MONA; Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV collagenase); Matrix Metallopeptidase 2; Matrix Metalloproteinase-II

Species:

Human

Source:

HEK293

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7

Neutral protease, Paenibacillus polymyxa

7 Cited Publications

Cat. No.: HY-131577

CAS No.: 42613-33-2

Synonyms: Dispase II, Dispase

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum .

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7

Buloxibutid

7 Cited Publications

Cat. No.: HY-100113

CAS No.: 477775-14-7

Purity: 99.02%

Synonyms: AT2 receptor agonist C21

Target:

Angiotensin Receptor p38 MAPK TGF-beta/Smad TGF-β Receptor MMP

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Buloxibutid (AT2 receptor agonist C21) is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a K_i value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis .

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4

MMP-9 Protein, Mouse (HEK293)

4 Cited Publications

Cat. No.: HY-P73807

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: MMP9; Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV collagenase); Prev. CLG4B; Macrophage Gelatinase; Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV collagenase); Type V collagenase; Matrix Metalloprot

Species:

Mouse

Source:

HEK293

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3

MMP-2 Protein, Human (HEK293, His)

3 Cited Publications

Cat. No.: HY-P70268

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: MMP2; Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV collagenase); Prev. CLG4A; collagenase Type IV-A; Prev. CLG4; Neutrophil Gelatinase; TBE-1; 72 KDa Gelatinase; MMP-2; Gelatinase A; 72 KDa Type IV collagenase; MMP-II; Matrix Metalloproteinase-2; MONA; Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV collagenase); Matrix Metallopeptidase 2; Matrix Metalloproteinase-II

Species:

Human

Source:

HEK293

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